Linked Life Data

16023861

Source:http://linkedlifedata.com/resource/pubmed/id/16023861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-11-21
pubmed:abstractText
Several nuclear hormone receptors have been associated with inflammatory reactions. Particularly, liver X receptors (LXRs) have recently been identified as key transcriptional regulators of genes involved in lipid homeostasis and inflammation. LXRs are negative regulators of macrophage inflammatory gene expression. Multiple sclerosis (MS), a demyelinating disease of the central nervous system of unknown cause, is characterized by recurrent inflammation involving macrophages and their inflammatory mediators. Sweden belongs to the countries with a high MS incidence. In Italy, the MS incidence is lower, except on the island of Sardinia where the incidence is even higher than in Sweden. Subjects from Sardinia are ethnically more homogeneous, and differ from Swedes also regarding genetic background and environment. We studied mRNA expression of several nuclear hormone receptors in blood mononuclear cells (MNC) from female patients with untreated relapsing-remitting MS from Sassari, Sardinia, and Stockholm, Sweden. Sex- and age-matched healthy controls (HC) were from both areas. mRNA expression was evaluated by quantitative real-time PCR. We found altered mRNA expression of LXRs, estrogen receptors (ERs), and androgen receptor (AR) in MS. mRNA expression of both LXRalpha and LXRbeta is lower in MS from Stockholm but not from Sassari. In particular, LXRalpha mRNA expression was significantly lower in MS from Stockholm as compared with all groups in the study including MS from Sassari. Low levels of ERalpha mRNA are seen in MS from both Stockholm and Sassari. The splice variant ERbetacx showed significantly higher mRNA expression in MS from Sassari and Stockholm as compared with corresponding HC. In particular, ERbetacx mRNA in MS from Sassari was remarkably higher as compared with all other groups in the study. Higher levels of AR mRNA are present in HC from Sassari. The findings indicate that the expression levels of anti-inflammatory nuclear receptor superfamily genes in MS appear to reflect both ethnic and environmental influences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0969-9961
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
961-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16023861-Adult, pubmed-meshheading:16023861-DNA-Binding Proteins, pubmed-meshheading:16023861-Estrogen Receptor alpha, pubmed-meshheading:16023861-Estrogen Receptor beta, pubmed-meshheading:16023861-Ethnic Groups, pubmed-meshheading:16023861-Female, pubmed-meshheading:16023861-Genetic Predisposition to Disease, pubmed-meshheading:16023861-Geography, pubmed-meshheading:16023861-Humans, pubmed-meshheading:16023861-Inflammation Mediators, pubmed-meshheading:16023861-Italy, pubmed-meshheading:16023861-Leukocytes, Mononuclear, pubmed-meshheading:16023861-Macrophages, pubmed-meshheading:16023861-Middle Aged, pubmed-meshheading:16023861-Multiple Sclerosis, pubmed-meshheading:16023861-Orphan Nuclear Receptors, pubmed-meshheading:16023861-RNA, Messenger, pubmed-meshheading:16023861-Receptors, Androgen, pubmed-meshheading:16023861-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:16023861-Receptors, Estrogen, pubmed-meshheading:16023861-Sweden
pubmed:year
2005
pubmed:articleTitle
Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden.
pubmed:affiliation
Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't