| pubmed-article:16023604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C1086056 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C0033692 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:16023604 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:16023604 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16023604 | pubmed:dateCreated | 2005-7-18 | lld:pubmed |
| pubmed-article:16023604 | pubmed:abstractText | Water-soluble proteoglycan (WSPG) of Agaricus blazei Murill has been known to stimulate the non-specific complements and humoral immune functions to act as polyclonal activators of B cells and to inhibit tumor growth and metastasis. However, little is known about its immunomodulating effects on murine bone marrow (BM)-derived dendritic cells (DC). In the present study, we examined the maturation process of murine BM-DC. BM cells were cultured in the presence of IL-4 and GM-CSF and the generated immature DC were stimulated with WSPG or LPS (WSPG-DC and LPS-DC, respectively) for 24 h. WSPG significantly enhanced the expression of co-stimulatory molecules (CD80 and CD86) and major histocompatibility complex (MHC) II, as did LPS. IL-12p70 production in WSPG-DC was also identical to that in LPS-DC. The antigen-uptake capacity of WSPG-DC was determined by FITC-labeled dextran uptake. WSPG-DC lost dextran uptake capacity comparable to LPS-DC. The antigen-presenting capacity of WSPG-DC as analyzed by allogeneic T cell proliferation was significantly increased in comparison with immature DC, was identical to LPS-DC, and induced higher levels of IL-2 in responding T cells. These results indicate the immunomodulatory properties of WSPG, which might be therapeutically useful in the control of cancers and immunodeficient diseases through the up-regulation of DC maturation. | lld:pubmed |
| pubmed-article:16023604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16023604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16023604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16023604 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16023604 | pubmed:issn | 1567-5769 | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:ChoiYung... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:LeeMoo-YeolMY | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:ChungKyung... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:KimGi-YoungGY | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:ParkYeong-Min... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:JeongYong-Kee... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:LeeJae-YunJY | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:ChoiIn-HakIH | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:LeeHee-JeongH... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:MoonDong-OhDO | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:LeeChang-MinC... | lld:pubmed |
| pubmed-article:16023604 | pubmed:author | pubmed-author:JinCheng-YunC... | lld:pubmed |
| pubmed-article:16023604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16023604 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:16023604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16023604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16023604 | pubmed:pagination | 1523-32 | lld:pubmed |
| pubmed-article:16023604 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16023604 | pubmed:meshHeading | pubmed-meshheading:16023604... | lld:pubmed |
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| pubmed-article:16023604 | pubmed:meshHeading | pubmed-meshheading:16023604... | lld:pubmed |
| pubmed-article:16023604 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16023604 | pubmed:articleTitle | Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells. | lld:pubmed |
| pubmed-article:16023604 | pubmed:affiliation | Department of Microbiology and Medical Research Institute, Pusan National University, College of Medicine, Ami-dong 1-10, Seo-gu, Pusan 602-739, Republic of Korea. | lld:pubmed |
| pubmed-article:16023604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16023604 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16023604 | lld:pubmed |
