Source:http://linkedlifedata.com/resource/pubmed/id/16023604
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2005-7-18
|
| pubmed:abstractText |
Water-soluble proteoglycan (WSPG) of Agaricus blazei Murill has been known to stimulate the non-specific complements and humoral immune functions to act as polyclonal activators of B cells and to inhibit tumor growth and metastasis. However, little is known about its immunomodulating effects on murine bone marrow (BM)-derived dendritic cells (DC). In the present study, we examined the maturation process of murine BM-DC. BM cells were cultured in the presence of IL-4 and GM-CSF and the generated immature DC were stimulated with WSPG or LPS (WSPG-DC and LPS-DC, respectively) for 24 h. WSPG significantly enhanced the expression of co-stimulatory molecules (CD80 and CD86) and major histocompatibility complex (MHC) II, as did LPS. IL-12p70 production in WSPG-DC was also identical to that in LPS-DC. The antigen-uptake capacity of WSPG-DC was determined by FITC-labeled dextran uptake. WSPG-DC lost dextran uptake capacity comparable to LPS-DC. The antigen-presenting capacity of WSPG-DC as analyzed by allogeneic T cell proliferation was significantly increased in comparison with immature DC, was identical to LPS-DC, and induced higher levels of IL-2 in responding T cells. These results indicate the immunomodulatory properties of WSPG, which might be therapeutically useful in the control of cancers and immunodeficient diseases through the up-regulation of DC maturation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Water
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1567-5769
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| pubmed:author |
pubmed-author:ChoiIn-HakIH,
pubmed-author:ChoiYung HyunYH,
pubmed-author:ChungKyung TaeKT,
pubmed-author:JeongYong-KeeYK,
pubmed-author:JinCheng-YunCY,
pubmed-author:KimGi-YoungGY,
pubmed-author:LeeChang-MinCM,
pubmed-author:LeeHee-JeongHJ,
pubmed-author:LeeJae-YunJY,
pubmed-author:LeeMoo-YeolMY,
pubmed-author:MoonDong-OhDO,
pubmed-author:ParkYeong-MinYM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1523-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16023604-Agaricus,
pubmed-meshheading:16023604-Animals,
pubmed-meshheading:16023604-Antigens, CD80,
pubmed-meshheading:16023604-Bone Marrow Cells,
pubmed-meshheading:16023604-Cell Differentiation,
pubmed-meshheading:16023604-Cell Proliferation,
pubmed-meshheading:16023604-Cells, Cultured,
pubmed-meshheading:16023604-Dendritic Cells,
pubmed-meshheading:16023604-Histocompatibility Antigens Class II,
pubmed-meshheading:16023604-Interleukin-12,
pubmed-meshheading:16023604-Interleukin-2,
pubmed-meshheading:16023604-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:16023604-Male,
pubmed-meshheading:16023604-Mice,
pubmed-meshheading:16023604-Mice, Inbred C57BL,
pubmed-meshheading:16023604-Proteoglycans,
pubmed-meshheading:16023604-Solubility,
pubmed-meshheading:16023604-T-Lymphocytes,
pubmed-meshheading:16023604-Water
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells.
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| pubmed:affiliation |
Department of Microbiology and Medical Research Institute, Pusan National University, College of Medicine, Ami-dong 1-10, Seo-gu, Pusan 602-739, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|