Source:http://linkedlifedata.com/resource/pubmed/id/16023187
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2005-8-22
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| pubmed:abstractText |
The aim of the present study was to investigate the neurobehavioral protective efficacy of a hydroalcoholic extract of ginger (Zingiber officinale Rosc.) in mitigating gamma radiation-induced conditioned taste aversion in Sprague-Dawley rats. Administration of Zingiber extract 1 h before 2-Gy gamma irradiation was effective in blocking the saccharin avoidance response for 5 post-treatment observational days, both in a dose- and time-dependent manner, with 200 mg/kg b.w. i.p. being the most effective dose. Highest saccharin intake in all the groups was observed on the fifth post-treatment day. The potential of ginger extract to inhibit lipid peroxidation induced by radiation (2 Gy) and ascorbate-ion stress in brain homogenate and its ability to scavenge highly reactive superoxide anions were evaluated. The 1000-microg/ml and 2000-microg/ml concentration of ginger extract showed the highest efficiency in scavenging free radicals and in inhibiting lipid peroxidation. The lipid peroxidation and superoxide-anion scavenging ability of the extract further supports its radioprotective properties. The results clearly establish the neurobehavioral efficacy of ginger extract and the antioxidant properties appear to be a contributing factor in its overall ability to modulate radiation-induced conditioned taste aversion. Ginger extract has tremendous potential for clinical applications in mitigation of radiation-induced emesis in humans.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharin,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0091-3057
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
81
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
864-70
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16023187-Animals,
pubmed-meshheading:16023187-Body Weight,
pubmed-meshheading:16023187-Brain,
pubmed-meshheading:16023187-Conditioning (Psychology),
pubmed-meshheading:16023187-Dose-Response Relationship, Drug,
pubmed-meshheading:16023187-Drinking Behavior,
pubmed-meshheading:16023187-Free Radical Scavengers,
pubmed-meshheading:16023187-Gamma Rays,
pubmed-meshheading:16023187-Ginger,
pubmed-meshheading:16023187-Lipid Peroxidation,
pubmed-meshheading:16023187-Male,
pubmed-meshheading:16023187-Malondialdehyde,
pubmed-meshheading:16023187-Plant Extracts,
pubmed-meshheading:16023187-Rats,
pubmed-meshheading:16023187-Rats, Sprague-Dawley,
pubmed-meshheading:16023187-Saccharin,
pubmed-meshheading:16023187-Taste,
pubmed-meshheading:16023187-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:16023187-Time Factors
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| pubmed:year |
2005
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| pubmed:articleTitle |
Zingiber officinale Rosc. modulates gamma radiation-induced conditioned taste aversion.
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| pubmed:affiliation |
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 054, India.
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| pubmed:publicationType |
Journal Article,
Comparative Study
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