Linked Life Data

16021566

Source:http://linkedlifedata.com/resource/pubmed/id/16021566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-7-15
pubmed:abstractText
Diagnosis of synchronous endometrioid carcinomas of the uterine corpus and ovary as either separate independent primary or as metastatic tumors requires careful consideration of a number of gross and histological features. Although such assessment is often sufficient, recent evidence has suggested that molecular analysis may facilitate the diagnosis in problematic cases. Furthermore, as independent synchronous tumors limited to the uterus and ovary are generally associated with favorable outcome, determination of genetic alterations associated with this group of neoplasms may indicate molecular markers of less aggressive behavior. We examined 12 cases of synchronous carcinomas of the uterus and ovary, correlating conventional gross and histological parameters with molecular genetic alterations common to single endometrioid carcinomas occurring in these sites. We identified a frequency of molecular alterations in both independent and metastatic tumors, including microsatellite instability (uterine tumors, 50% and 67%, respectively; ovarian tumors, 33% and 67%) and PTEN mutations (uterine tumors, 38% and 100%; ovarian tumors, 33% and 83%) that is higher than that observed in single sporadic tumors. Loss of heterozygosity for chromosome 17p and 10q was also frequently observed. Nuclear immunoreactivities for beta -catenin and CTNNB1 mutations were restricted to independent uterine and ovarian tumors and were absent in all of the metastatic tumors, providing direct evidence for a divergence of molecular oncogenetic mechanisms in the subset of synchronous endometrioid carcinomas. Furthermore, our data show that molecular genetic classification of synchronous independent versus metastatic tumors based on beta -catenin expression/mutation correlates with clinical outcome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-19
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16021566-Adult, pubmed-meshheading:16021566-Aged, pubmed-meshheading:16021566-Base Sequence, pubmed-meshheading:16021566-Carcinoma, Endometrioid, pubmed-meshheading:16021566-Cytoskeletal Proteins, pubmed-meshheading:16021566-DNA Mutational Analysis, pubmed-meshheading:16021566-Diagnosis, Differential, pubmed-meshheading:16021566-Female, pubmed-meshheading:16021566-Humans, pubmed-meshheading:16021566-Immunohistochemistry, pubmed-meshheading:16021566-Loss of Heterozygosity, pubmed-meshheading:16021566-Microsatellite Repeats, pubmed-meshheading:16021566-Middle Aged, pubmed-meshheading:16021566-Mutation, pubmed-meshheading:16021566-Neoplasms, Multiple Primary, pubmed-meshheading:16021566-Ovarian Neoplasms, pubmed-meshheading:16021566-Polymerase Chain Reaction, pubmed-meshheading:16021566-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:16021566-Prognosis, pubmed-meshheading:16021566-Trans-Activators, pubmed-meshheading:16021566-Tumor Markers, Biological, pubmed-meshheading:16021566-Uterine Neoplasms, pubmed-meshheading:16021566-beta Catenin
pubmed:year
2005
pubmed:articleTitle
Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis.
pubmed:affiliation
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't