Linked Life Data

16021427

Source:http://linkedlifedata.com/resource/pubmed/id/16021427

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-9-5
pubmed:abstractText
The separation behavior of the frequently administered pharmaceuticals sulfamethoxazol (Sulfa), carbamazepine (Carba), diclofenac (Diclo), and ibuprofen (Ibu) on different natural and synthetic ultrafiltration membranes was studied. Commercially available cattle intestine natural membranes (NM), polyethersulfone (PES), and regenerated cellulose-based (RC) flat membranes (nominal cut-off 1 kDa) have been investigated as ultrafiltration membranes in a small tangential-flow ultrafiltration unit (TF-UF). First, the nominal cut-off of the NM membranes under study was assessed at approximately 5 kDa, by using polystyrenesulfonate standards for pore-size classification at low TF-UF pressure (0.25 x 10(5) Pa). Working pressures of >1.5 x 10(5) Pa strongly increased the cut-off of NM, in contrast with that of PES and RC membranes. Sulfa, Carba, Diclo and Ibu (1 mg L(-1) each) in colloid-free aqueous solutions (400 mg L(-1) NaCl) completely permeated through NM membranes, but less through PES and RC, which had particular sorption capability towards Diclo. The drugs were routinely determined by using high-performance liquid chromatography (HPLC). Detailed TF-UF investigation of drug retention on NM in the presence of humic hydrocolloids revealed strong interactions between aquatic humic substances (HS) and Diclo and Ibu (but not with Sulfa and Carba) causing retention of up to 80% of Diclo and Ibu, probably because of their binding to macromolecular HS. The standard deviation (SD) of both drug and HS permeation through a single NM was between 2.5 (Sulfa) and 4.0% (Diclo), in contrast with the SD of permeation through separate membranes taken from different lots [SD up to 14.0% (Diclo)], presumably caused by natural variation of the studied NM. Accordingly, membrane filtration of drug-containing water samples on cattle intestines enables both analyte/matrix separations for Carba and Sulfa in the presence of humic colloids and analytical discrimination between free and colloid-bound Diclo and Ibu fractions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1618-2642
pubmed:author
pubmed:issnType
Print
pubmed:volume
382
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1934-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Ultrafiltration behavior of selected pharmaceuticals on natural and synthetic membranes in the presence of humic-rich hydrocolloids.
pubmed:affiliation
ISAS, Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, 44139 Dortmund, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't