|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0030705,
umls-concept:C0205210,
umls-concept:C0332183,
umls-concept:C0441471,
umls-concept:C0442027,
umls-concept:C0449432,
umls-concept:C0681842,
umls-concept:C0878500,
umls-concept:C1179435,
umls-concept:C1274040,
umls-concept:C1515926,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1704259,
umls-concept:C1705248,
umls-concept:C1705987
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|
pubmed:issue |
4-6
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|
pubmed:dateCreated |
2005-8-16
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|
pubmed:abstractText |
This study was designed to test the hypothesis that alterations in expression of G1/S modulators cyclin D1, p16 and pRb occur in patients with oral epithelial dysplasia, considered to be at increased risk for malignant transformation. In addition, the analysis of expression of all three markers in the same set of oral cancer patients would provide a unique opportunity to determine whether these alterations have cooperative or synergistic effects on oral cancer development and prognosis.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0030-2414
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2005 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
314-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16020958-Adult,
pubmed-meshheading:16020958-Aged,
pubmed-meshheading:16020958-Aged, 80 and over,
pubmed-meshheading:16020958-Carcinoma, Squamous Cell,
pubmed-meshheading:16020958-Case-Control Studies,
pubmed-meshheading:16020958-Cyclin D1,
pubmed-meshheading:16020958-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:16020958-Epithelial Cells,
pubmed-meshheading:16020958-Female,
pubmed-meshheading:16020958-Humans,
pubmed-meshheading:16020958-Leukoplakia, Oral,
pubmed-meshheading:16020958-Male,
pubmed-meshheading:16020958-Middle Aged,
pubmed-meshheading:16020958-Mouth Mucosa,
pubmed-meshheading:16020958-Mouth Neoplasms,
pubmed-meshheading:16020958-Neoplasm Invasiveness,
pubmed-meshheading:16020958-Neoplasm Staging,
pubmed-meshheading:16020958-Prognosis,
pubmed-meshheading:16020958-Prospective Studies,
pubmed-meshheading:16020958-Retinoblastoma Protein,
pubmed-meshheading:16020958-Tumor Markers, Biological,
pubmed-meshheading:16020958-Tumor Suppressor Protein p53
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pubmed:year |
2005
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pubmed:articleTitle |
Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma.
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|
pubmed:affiliation |
Department of Biochemistry, Institute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
