Source:http://linkedlifedata.com/resource/pubmed/id/16020471
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
18
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pubmed:dateCreated |
2005-9-1
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pubmed:abstractText |
Multiple sequence alignment is an essential part of bioinformatics tools for a genome-scale study of genes and their evolution relations. However, making an accurate alignment between remote homologs is challenging. Here, we develop a method, called SPEM, that aligns multiple sequences using pre-processed sequence profiles and predicted secondary structures for pairwise alignment, consistency-based scoring for refinement of the pairwise alignment and a progressive algorithm for final multiple alignment.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1367-4803
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3615-21
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16020471-Algorithms,
pubmed-meshheading:16020471-Amino Acid Sequence,
pubmed-meshheading:16020471-Computational Biology,
pubmed-meshheading:16020471-Computing Methodologies,
pubmed-meshheading:16020471-Databases, Protein,
pubmed-meshheading:16020471-Evolution, Molecular,
pubmed-meshheading:16020471-Internet,
pubmed-meshheading:16020471-Protein Folding,
pubmed-meshheading:16020471-Protein Structure, Secondary,
pubmed-meshheading:16020471-Sequence Alignment,
pubmed-meshheading:16020471-Sequence Analysis, Protein,
pubmed-meshheading:16020471-Sequence Homology, Amino Acid,
pubmed-meshheading:16020471-Software
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pubmed:year |
2005
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pubmed:articleTitle |
SPEM: improving multiple sequence alignment with sequence profiles and predicted secondary structures.
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pubmed:affiliation |
Department of Physiology and Biophysics, Howard Hughes Medical Institute Center for Single Molecule Biophysics, State University of New York, Buffalo, NY 14214, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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