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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-7-15
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pubmed:abstractText |
After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0265-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-57
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16019851-Animals,
pubmed-meshheading:16019851-Antigens, CD3,
pubmed-meshheading:16019851-Cancer Vaccines,
pubmed-meshheading:16019851-Carcinoma, Lewis Lung,
pubmed-meshheading:16019851-Cell Line, Tumor,
pubmed-meshheading:16019851-Electrocoagulation,
pubmed-meshheading:16019851-Female,
pubmed-meshheading:16019851-Graft Rejection,
pubmed-meshheading:16019851-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:16019851-Humans,
pubmed-meshheading:16019851-Interleukin-2,
pubmed-meshheading:16019851-Killer Cells, Natural,
pubmed-meshheading:16019851-Lung Neoplasms,
pubmed-meshheading:16019851-Male,
pubmed-meshheading:16019851-Mice,
pubmed-meshheading:16019851-Mice, Inbred C57BL,
pubmed-meshheading:16019851-Microspheres,
pubmed-meshheading:16019851-Microwaves,
pubmed-meshheading:16019851-Neoplasm Transplantation,
pubmed-meshheading:16019851-Recombinant Proteins,
pubmed-meshheading:16019851-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16019851-Tumor Burden
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pubmed:year |
2005
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pubmed:articleTitle |
Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.
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pubmed:affiliation |
The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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