Linked Life Data

16015408

Source:http://linkedlifedata.com/resource/pubmed/id/16015408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-7-14
pubmed:abstractText
The aim of this study was to prospectively assess associations between amaurosis fugax, inherited thrombophilia, and acquired thrombophilia. Thrombophilia and hypofibrinolysis were studied in 11 cases (eight women, three men; all white) with amaurosis fugax, 57 +/- 17 years old, selected by the absence of abnormal brain magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), magnetic resonance venography (MRV), ipsilateral internal carotid artery plaque, atrial fibrillation, or cardiac thrombus. Cases were compared to 78 healthy adult white controls (53 +/- 18 years old) for serologic measures, and by polymerase chain reaction to 248 healthy white controls (78 adults, 170 children) for gene mutations. All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous for the G1691A factor V Leiden mutation, two with low free protein S, four with high factor VIII, three with resistance to activated protein C, three homozygous for the C677T methylenetetrahydrofolate reductase (MTHFR) mutation, two compound C677T-A1298C MTHFR heterozygotes, and three with hypofibrinolytic 4G4G homozygosity for the PAI-1 gene. The case with factor VIII of 160% had two other thrombophilias (compound MTHFR C677T-A1298C heterozygosity, resistance to activated protein C), and hypofibrinolytic high Lp(a). Thrombophilic C677T MTHFR homozygosity or compound C677T-A1298C heterozygosity was present in five of 10 (50%) cases vs. 30 of 248 (12%) controls, Fisher's p (p(f)) = .005. Thrombophilic factor VIII was high in four of 10 (40%) cases vs. 0 of 38 controls, p(f) = .001. Thrombophilic hyperestrogenemia in five of the eight women (four exogenous estrogen, one pregnant) may have interacted with inherited thrombophilia-hypofibrinolysis, promoting thrombus formation. In cases selected by the absence of abnormal brain magnetic resonance imaging, significant ipsilateral internal carotid artery plaque, atrial fibrillation, or cardiac thrombus, we speculate that amaurosis fugax can be caused by reversible (by anticoagulation) retinal artery thrombi associated with heritable thrombophilia and/or hypofibrinolysis, often augmented by estrogen-driven acquired thrombophilia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1076-0296
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16015408-Adult, pubmed-meshheading:16015408-Aged, pubmed-meshheading:16015408-Amaurosis Fugax, pubmed-meshheading:16015408-Amino Acid Substitution, pubmed-meshheading:16015408-Brain, pubmed-meshheading:16015408-Child, pubmed-meshheading:16015408-Factor VIII, pubmed-meshheading:16015408-Female, pubmed-meshheading:16015408-Heterozygote Detection, pubmed-meshheading:16015408-Homozygote, pubmed-meshheading:16015408-Humans, pubmed-meshheading:16015408-Magnetic Resonance Imaging, pubmed-meshheading:16015408-Male, pubmed-meshheading:16015408-Methylenetetrahydrofolate Reductase (NADPH2), pubmed-meshheading:16015408-Middle Aged, pubmed-meshheading:16015408-Plasminogen Activator Inhibitor 1, pubmed-meshheading:16015408-Polymorphism, Single Nucleotide, pubmed-meshheading:16015408-Reference Values, pubmed-meshheading:16015408-Thrombophilia
pubmed:year
2005
pubmed:articleTitle
Amaurosis fugax: associations with heritable thrombophilia.
pubmed:affiliation
Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't