16015035

Source:http://linkedlifedata.com/resource/pubmed/id/16015035

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007102, umls-concept:C0018270, umls-concept:C0078058, umls-concept:C0215737, umls-concept:C0334227, umls-concept:C0378796, umls-concept:C0596138, umls-concept:C1171892, umls-concept:C1257954, umls-concept:C1521840, umls-concept:C1704259, umls-concept:C1705987, umls-concept:C1882932
pubmed:issue	2-3
pubmed:dateCreated	2005-8-9
pubmed:abstractText	Coexpression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) has been reported in tumor cells, suggesting the presence of an autocrine VEGF/VEGFR-2 growth pathway in solid tumors. Thus, we hypothesize that the presence of this autocrine pathway in colon cancer cells may be a COX-2-independent target of COX-2 inhibitors and a mechanism behind the antitumor effects of these agents.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0135054
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met..., http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...
pubmed:status	MEDLINE
pubmed:issn	0030-2414
pubmed:author	pubmed-author:ChoiChul WonCW, pubmed-author:KimByung SooBS, pubmed-author:KimJun SukJS, pubmed-author:KimSeok JinSJ, pubmed-author:KimYeul HongYH, pubmed-author:LeeYoo JungYJ, pubmed-author:SeoJae HongJH, pubmed-author:ShinSang WonSW, pubmed-author:YoonJi HyeJH
pubmed:copyrightInfo	Copyright (c) 2005 S. Karger AG, Basel.
pubmed:issnType	Print
pubmed:volume	68
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	204-11
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:16015035-Antineoplastic Agents, pubmed-meshheading:16015035-Blotting, Western, pubmed-meshheading:16015035-Caco-2 Cells, pubmed-meshheading:16015035-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:16015035-Cell Line, Tumor, pubmed-meshheading:16015035-Cell Proliferation, pubmed-meshheading:16015035-Colonic Neoplasms, pubmed-meshheading:16015035-Cyclooxygenase Inhibitors, pubmed-meshheading:16015035-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:16015035-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16015035-HT29 Cells, pubmed-meshheading:16015035-Humans, pubmed-meshheading:16015035-Lung Neoplasms, pubmed-meshheading:16015035-Nitrobenzenes, pubmed-meshheading:16015035-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16015035-Sulfonamides, pubmed-meshheading:16015035-Vascular Endothelial Growth Factor A, pubmed-meshheading:16015035-Vascular Endothelial Growth Factor Receptor-2
pubmed:year	2005
pubmed:articleTitle	Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells.
pubmed:affiliation	Division of Oncology and Hematology, Department of Internal Medicine, College of Medicine, Korea University, Kozan-1 Dong, Ansan City, Kyoung-ki, Seoul, Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't