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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2005-7-14
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pubmed:abstractText |
Elimination of viral infections is dependent on rapid recruitment and activation of leukocytes with antiviral activities to infected areas. Chemokines constitute a class of cytokines that have regulatory effects on leukocyte migration and activity. In this study we have studied the role of CC chemokine receptor 1 (CCR1) and CCR5 in host defense during a generalized herpes simplex virus type 2 (HSV-2) infection. Whereas both 4- and 8-week-old CCR1(-/-) mice resembled wild-type mice (C57BL/6) with respect to defense against the infection, significantly higher virus titers were seen in the livers and brains of 4-week-old CCR5(-/-) mice. At the age of 8 weeks, CCR5(-/-) were indistinguishable from wild-type mice and cleared the infection from liver and spleen. Although 4-week-old CCR5(-/-) mice were able to recruit natural killer (NK) cells to the site of infection, these cells had reduced cytotoxic activity compared to NK cells from wild-type mice. This was not due to lower production of alpha/beta interferon or interleukin-12, two well-described activators of cytotoxic activity in NK cells. We also noted that the spleens of young CCR5(-/-) mice did not increase in size during infection as did the spleens of wild-type and CCR1(-/-) mice. This observation was accompanied by impaired proliferation of CCR5(-/-) splenocytes (SCs) ex vivo. Moreover, migration of CD8(+) T cells to the liver in response to infection was impaired in CCR5(-/-) mice, and adoptive transfer of SCs from CCR5(-/-) mice infected for 6 days into newly infected wild-type mice did not improve antiviral activity in the liver, in contrast to what was seen in mice receiving immune SCs from wild-type mice. Altogether, this study shows that CCR5 plays an age-dependent role in host defense against HSV-2 by supporting both the innate and adaptive immune response.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10073287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10358757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10528159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10657652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10749577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10837080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10854218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10881180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-10946298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11160225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11161432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11543653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11790543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11830471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-11907072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12055576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12391255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12414723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12539043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12563297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12797544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12949236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-12974476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-14165331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-14597739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-14623909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-14647058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-14742553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-203536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-7667639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-8648121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-9166425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-9419206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-9557652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16014944-9768627
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9831-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16014944-Age Factors,
pubmed-meshheading:16014944-Animals,
pubmed-meshheading:16014944-Herpes Simplex,
pubmed-meshheading:16014944-Herpesvirus 2, Human,
pubmed-meshheading:16014944-Immunity, Active,
pubmed-meshheading:16014944-Immunity, Innate,
pubmed-meshheading:16014944-Mice,
pubmed-meshheading:16014944-Mice, Inbred C57BL,
pubmed-meshheading:16014944-Mice, Knockout,
pubmed-meshheading:16014944-Receptors, CCR5
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pubmed:year |
2005
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pubmed:articleTitle |
Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2.
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pubmed:affiliation |
Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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