| pubmed-article:16014574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0011848 | lld:lifeskim |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:16014574 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
| pubmed-article:16014574 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16014574 | pubmed:dateCreated | 2005-11-8 | lld:pubmed |
| pubmed-article:16014574 | pubmed:abstractText | This study compared the renal metabolism of arachidonic acid in Brattleboro (BB) (vasopressin deficient) and Long-Evans (LE) control rats and the effects of a cytochrome P-450 (CYP) inhibitor 1-aminobenzotriazole (ABT) on renal function in these animals. The production of 20-hydroxyeicosatetraenoic acid (20-HETE) by renal cortical and outer medullary microsomes was significantly greater in BB than in LE rats (155 +/- 16 vs. 92 +/- 13 and 59 +/- 7 vs. 33 +/- 3 pmol.min(-1).mg protein(-1)). Renal cortical epoxygenase activity was not different in these strains. The expression of CYP4A proteins was 58 and 78% higher in the renal cortex and outer medulla of BB than in LE rats. Chronic treatment of BB rats with a vasopressin type 2 receptor agonist for 1 wk normalized the renal production of 20-HETE. Chronic blockade of the formation of 20-HETE and EETs with ABT had little effect on renal function in LE rats. However, urine flow increased by 54% and urine osmolarity decreased by 33% in BB rats treated with ABT. Plasma levels of oxytocin fell significantly from 7.2 +/- 1.3 to 3.9 +/- 1.0 pg/ml. The effects of ABT in BB rats were attenuated by chronic infusion of oxytocin (0.7 ng.min(-1).100 g(-1)) to maintain fixed high plasma levels of this hormone. These results indicate that the expression of CYP4A protein and the renal formation of 20-HETE are elevated in the kidney of BB rats due to a lack of vasopressin and that chronic blockade of the formation of 20-HETE and EETs with ABT promotes water excretion in vasopressin-deficient BB rats by reducing the circulating levels of oxytocin, which is a weak vasopressin agonist. | lld:pubmed |
| pubmed-article:16014574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16014574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16014574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16014574 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16014574 | pubmed:issn | 1931-857X | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:RomanRichard... | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:ItoSadayoshiS | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:ItoOsamuO | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:CowleyAllen... | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:MoriTakefumiT | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:KohzukiMasahi... | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:VerbalisJosep... | lld:pubmed |
| pubmed-article:16014574 | pubmed:author | pubmed-author:SarkisAlbertA | lld:pubmed |
| pubmed-article:16014574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16014574 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:16014574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16014574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16014574 | pubmed:pagination | F1333-40 | lld:pubmed |
| pubmed-article:16014574 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
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| pubmed-article:16014574 | pubmed:meshHeading | pubmed-meshheading:16014574... | lld:pubmed |
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| pubmed-article:16014574 | pubmed:meshHeading | pubmed-meshheading:16014574... | lld:pubmed |
| pubmed-article:16014574 | pubmed:meshHeading | pubmed-meshheading:16014574... | lld:pubmed |
| pubmed-article:16014574 | pubmed:meshHeading | pubmed-meshheading:16014574... | lld:pubmed |
| pubmed-article:16014574 | pubmed:meshHeading | pubmed-meshheading:16014574... | lld:pubmed |
| pubmed-article:16014574 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16014574 | pubmed:articleTitle | Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. | lld:pubmed |
| pubmed-article:16014574 | pubmed:affiliation | Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA. | lld:pubmed |
| pubmed-article:16014574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16014574 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16014574 | lld:pubmed |
