Source:http://linkedlifedata.com/resource/pubmed/id/16014568
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2005-10-20
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pubmed:abstractText |
We previously observed a loss of Epstein-Barr virus (EBV)-specific CD8+ T cells in subjects progressing to EBV-related non-Hodgkin lymphoma (NHL), correlating with loss of CD4+ T cells. The aim of the present study was to determine the role of EBV-specific CD4+ T cells in the development of NHL during chronic HIV infection. To this end, CD4+ and CD8+ memory T cells, capable of both proliferation and subsequent interferon gamma (IFNgamma) production, directed against a latent (Epstein-Barr virus nuclear antigen 1 [EBNA1]) and a lytic (BamH fragment Z left frame 1 [BZLF1]) EBV antigen were studied longitudinally in 9 progressors to NHL, 4 progressors to non-EBV-related AIDS, and 4 slow progressors to AIDS. In all 3 groups we observed a decline of EBV-specific memory CD4+ and CD8+ T-cell responses during HIV infection. However, whereas latent antigen EBNA1-specific CD4+ T cells were lost well before diagnosis in all subjects who developed an AIDS-related NHL (and EBNA1-specific CD8+ T cells were significantly lower compared with the other groups), these cells were better preserved in progressors to non-EBV-related disease and slow progressors. Loss of EBNA1-specific T-cell immunity thus might be important for progression to NHL. Interestingly, BZLF1-specific T cells were not lost in all progressors to NHL, suggesting a different function of these cells in the surveillance of EBV-infected B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3166-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16014568-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16014568-Adult,
pubmed-meshheading:16014568-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16014568-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16014568-Cell Proliferation,
pubmed-meshheading:16014568-Disease Progression,
pubmed-meshheading:16014568-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:16014568-HIV-1,
pubmed-meshheading:16014568-Humans,
pubmed-meshheading:16014568-Immunologic Memory,
pubmed-meshheading:16014568-Kinetics,
pubmed-meshheading:16014568-Lymphoma, AIDS-Related,
pubmed-meshheading:16014568-Lymphoma, Non-Hodgkin,
pubmed-meshheading:16014568-Middle Aged
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pubmed:year |
2005
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pubmed:articleTitle |
Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma.
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pubmed:affiliation |
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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