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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-13
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pubmed:abstractText |
Transforming growth factor beta and its intracellular mediators, Smad proteins, play important roles in stimulating collagen gene transcription and, thus, could be the targets for treating hepatic fibrosis. However, intervention of transforming growth factor beta/Smad signaling affects physiological signal transduction as well and may cause serious adverse effects on clinical application. Here we have attempted to suppress hepatic fibrosis by expressing a transforming growth factor beta/Smad antagonist selectively in collagen-producing cells only in the fibrotic liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Tetrachloride,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Y-Box-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/YBX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/alpha 2(I) collagen
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:Bou-GhariosGeorgeG,
pubmed-author:HigashiKiyoshiK,
pubmed-author:HigashiyamaReiichiR,
pubmed-author:HongYun YuYY,
pubmed-author:IkedaKazuoK,
pubmed-author:InagakiYutakaY,
pubmed-author:ItohJohbuJ,
pubmed-author:KawadaNorifumiN,
pubmed-author:KiyamaHiroshiH,
pubmed-author:KushidaMiwaM,
pubmed-author:NamikawaKazuhikoK,
pubmed-author:OkazakiIsaoI,
pubmed-author:WatanabeTetsuT
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-68
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16012952-Adenoviridae,
pubmed-meshheading:16012952-Animals,
pubmed-meshheading:16012952-Carbon Tetrachloride,
pubmed-meshheading:16012952-Collagen,
pubmed-meshheading:16012952-Collagen Type I,
pubmed-meshheading:16012952-DNA-Binding Proteins,
pubmed-meshheading:16012952-Enhancer Elements, Genetic,
pubmed-meshheading:16012952-Gene Expression,
pubmed-meshheading:16012952-Gene Therapy,
pubmed-meshheading:16012952-Green Fluorescent Proteins,
pubmed-meshheading:16012952-Interferon-gamma,
pubmed-meshheading:16012952-Liver Cirrhosis,
pubmed-meshheading:16012952-Mice,
pubmed-meshheading:16012952-Mice, Transgenic,
pubmed-meshheading:16012952-Nuclear Proteins,
pubmed-meshheading:16012952-Promoter Regions, Genetic,
pubmed-meshheading:16012952-Rats,
pubmed-meshheading:16012952-Signal Transduction,
pubmed-meshheading:16012952-Smad Proteins,
pubmed-meshheading:16012952-Trans-Activators,
pubmed-meshheading:16012952-Transforming Growth Factor beta,
pubmed-meshheading:16012952-Y-Box-Binding Protein 1
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pubmed:year |
2005
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pubmed:articleTitle |
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.
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pubmed:affiliation |
Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan. yutakai@is.icc.u-tokai.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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