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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-13
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pubmed:abstractText |
Growth hormone (GH) is used to treat growth delay in children with Crohn's disease and in patients with short-bowel syndrome. GH can increase collagen accumulation in intestinal mesenchymal cells, raising concern that GH therapy could exacerbate fibrosis in patients with Crohn's disease. We tested if GH treatment altered inflammation or fibrosis during chronic, experimental granulomatous enterocolitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SOCS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
204-19
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16012948-Animals,
pubmed-meshheading:16012948-Cecum,
pubmed-meshheading:16012948-Chronic Disease,
pubmed-meshheading:16012948-Collagen,
pubmed-meshheading:16012948-Female,
pubmed-meshheading:16012948-Fibroblasts,
pubmed-meshheading:16012948-Fibrosis,
pubmed-meshheading:16012948-Gene Expression,
pubmed-meshheading:16012948-Granuloma,
pubmed-meshheading:16012948-Growth Hormone,
pubmed-meshheading:16012948-Inflammatory Bowel Diseases,
pubmed-meshheading:16012948-Insulin-Like Growth Factor I,
pubmed-meshheading:16012948-Interleukin-10,
pubmed-meshheading:16012948-Interleukin-6,
pubmed-meshheading:16012948-Joints,
pubmed-meshheading:16012948-Polysaccharides,
pubmed-meshheading:16012948-RNA, Messenger,
pubmed-meshheading:16012948-Rats,
pubmed-meshheading:16012948-Rats, Inbred Lew,
pubmed-meshheading:16012948-Repressor Proteins,
pubmed-meshheading:16012948-Severity of Illness Index,
pubmed-meshheading:16012948-Specific Pathogen-Free Organisms,
pubmed-meshheading:16012948-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:16012948-Transcription Factors,
pubmed-meshheading:16012948-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation.
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pubmed:affiliation |
Department of Cell and Molecular Pathology, The Univesity of North Carolina at Chapel Hill, 27599-7545, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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