Linked Life Data

16012337

Source:http://linkedlifedata.com/resource/pubmed/id/16012337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-7-13
pubmed:abstractText
Throughout life, neuromuscular junctions undergo dynamic changes, remodelling occurring through extension and withdrawal of motor nerve terminals in conjunction with changes in the distribution of acetylcholine receptors at the muscle endplate. However, relatively little is known about the fundamental processes by which nerve terminals are remodelled. These dynamic processes are likely to be driven by molecular motors. Previously, we have implicated myosins IIA and IIB as opposing motors influencing neuronal growth cone dynamics. Using confocal microscopy of neuromuscular junction preparations colabelled for myosin II isoforms and nerve terminal or muscle endplate markers, we demonstrate that both myosin IIA and myosin IIB are localized in nerve terminals. We propose roles for these motor proteins in junctional stabilization and destabilization.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1143-6
pubmed:dateRevised
2011-6-29
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals.
pubmed:affiliation
Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't