Linked Life Data

16011985

Source:http://linkedlifedata.com/resource/pubmed/id/16011985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-7-13
pubmed:abstractText
Amyloid deposition occurs commonly in the aging aortic media. We recently found that a 50 amino acid amyloid fibril protein, which we called medin, forms the fibrils of this amyloid form. Medin is an internal fragment of the 364 long precursor lactadherin, which is expressed by several kinds of cells including vascular smooth muscle cells. With the use of specific antibodies we have now studied the vascular distribution of medin (AMed) amyloid in a series of 18 individuals, 57 years of age and older. All individuals had widely spread AMed amyloid in the media of the thoracic aorta while this type of amyloid occurred less commonly in the abdominal aorta. In 8 of the 18 individuals, AMed-amyloid was also found in the basilar artery while the frequency was lower in other studied arteries. Amyloid was usually seen in close association with the internal elastic lamina. Analysis of proteins extracted from amyloid-rich aortic media showed presence of both lactadherin and medin. This study shows that AMed amyloid is not restricted to the aorta and the temporal artery but also occurs in other arteries, mainly in the upper part of the body. AMed amyloid has to be added to the forms of amyloid that may be seen in intracranial vessels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1350-6129
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-102
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body.
pubmed:affiliation
Department of Genetics and Pathology, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't