Linked Life Data

16010693

Source:http://linkedlifedata.com/resource/pubmed/id/16010693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-8-15
pubmed:abstractText
Activating germline mutations in the fibroblast growth factor receptor (FGFR) gene family have been identified in several dominantly inherited skeletal disorders; in the case of FGFR3, the same somatically arising mutations have also been isolated from a variety of tumour tissues. Whilst the role of FGFR2 mutations in congenital syndromes has been well documented, their relationship with cancer has not been clearly defined. Based on evidence that gain-of-function mutations in FGFR2 drive positive selection in adult spermatogonia, the present study investigated, by denaturing high-performance liquid chromatography (DHPLC), DNA sequencing, and restriction digestion, the prevalence of FGFR2 mutations in 58 tumour cell lines of various types, and 29 testicular germ cell tumour samples. Although sequence variations and allelic imbalance were identified in FGFR2, none of the previously documented dominant mutations was detected in any of the tumour types examined. This suggests that gain-of-function FGFR2 mutations are not commonly encountered in tumourigenesis and specifically excludes a major contribution in testicular tumours.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3417
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16010693-Acrocephalosyndactylia, pubmed-meshheading:16010693-Adult, pubmed-meshheading:16010693-Cell Transformation, Neoplastic, pubmed-meshheading:16010693-Chromatography, High Pressure Liquid, pubmed-meshheading:16010693-DNA, Neoplasm, pubmed-meshheading:16010693-DNA Mutational Analysis, pubmed-meshheading:16010693-Female, pubmed-meshheading:16010693-Germ-Line Mutation, pubmed-meshheading:16010693-Humans, pubmed-meshheading:16010693-Male, pubmed-meshheading:16010693-Neoplasms, Germ Cell and Embryonal, pubmed-meshheading:16010693-Receptor, Fibroblast Growth Factor, Type 2, pubmed-meshheading:16010693-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:16010693-Receptors, Fibroblast Growth Factor, pubmed-meshheading:16010693-Testicular Neoplasms, pubmed-meshheading:16010693-Tumor Cells, Cultured
pubmed:year
2005
pubmed:articleTitle
Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: investigating a potential link.
pubmed:affiliation
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DS, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't