Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-7-14
pubmed:abstractText
Two yeast genes, ARD1 and NAT1, are required for the expression of an N-terminal protein acetyltransferase. This activity is required for full repression of the silent mating type locus HML, for sporulation, and for entry into G0. While the NAT1 gene product is thought to be the catalytic subunit of the enzyme, the role of the ARD1 protein has remained unclear. We have used epitope tagged derivatives of ARD1 and NAT1 to provide biochemical evidence for the formation of an ARD1-NAT1 complex, and to show that both proteins are required for the N-terminal acetyltransferase activity. We also present evidence for the formation of ARD1-ARD1 homodimers. Deletion analysis suggests that the C-terminal region of ARD1 may be involved in the formation of both ARD1-ARD1 and ARD1-NAT1 complexes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-1311090, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2117703, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2455217, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2551674, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2680595, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2681143, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2844792, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2896548, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-2999980, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3115591, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3316986, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3530496, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3907857, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3907859, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-3915782, http://linkedlifedata.com/resource/pubmed/commentcorrection/1600941-6760197
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:geneSymbol
ARD1, NAT1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2087-93
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.
pubmed:affiliation
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't