16007571

Source:http://linkedlifedata.com/resource/pubmed/id/16007571

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008976, umls-concept:C0205307, umls-concept:C0871261, umls-concept:C1704632, umls-concept:C1706778, umls-concept:C1706817, umls-concept:C1707689, umls-concept:C1709707, umls-concept:C2911692
pubmed:issue	16
pubmed:dateCreated	2005-7-28
pubmed:abstractText	Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments. The adaptive design does not affect inference.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8215016
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0277-6715
pubmed:author	pubmed-author:AtkinsonA CAC, pubmed-author:BiswasAA
pubmed:copyrightInfo	Copyright 2005 John Wiley & Sons, Ltd
pubmed:issnType	Print
pubmed:day	30
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2477-92
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:16007571-Clinical Trials, Phase III as Topic, pubmed-meshheading:16007571-Humans, pubmed-meshheading:16007571-Models, Statistical, pubmed-meshheading:16007571-Randomized Controlled Trials as Topic, pubmed-meshheading:16007571-Research Design
pubmed:year	2005
pubmed:articleTitle	Adaptive biased-coin designs for skewing the allocation proportion in clinical trials with normal responses.
pubmed:affiliation	Department of Statistics, London School of Economics, UK. a.c.atkinson@lse.ac.uk
pubmed:publicationType	Journal Article, Comparative Study