|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2005-7-11
|
|
pubmed:abstractText |
Clarithromycin is frequently used to treat community-acquired pneumonia in elderly persons. Like erythromycin, it may interact with other drugs by interfering with metabolism by cytochrome P450 enzymes and with the P-glycoprotein transporter system. Colchicine, used for treatment of acute gout and for prophylaxis, may cause bone marrow toxicity. It is metabolized by CYP3A4 and is transported by P-glycoprotein. Initial case reports suggested potentially fatal interactions between clarithromycin and colchicine.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1537-6591
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
291-300
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16007523-Aged,
pubmed-meshheading:16007523-Aged, 80 and over,
pubmed-meshheading:16007523-Anti-Bacterial Agents,
pubmed-meshheading:16007523-Clarithromycin,
pubmed-meshheading:16007523-Colchicine,
pubmed-meshheading:16007523-Drug Interactions,
pubmed-meshheading:16007523-Female,
pubmed-meshheading:16007523-Gout Suppressants,
pubmed-meshheading:16007523-Humans,
pubmed-meshheading:16007523-Incidence,
pubmed-meshheading:16007523-Male,
pubmed-meshheading:16007523-Middle Aged,
pubmed-meshheading:16007523-Multivariate Analysis,
pubmed-meshheading:16007523-Renal Insufficiency,
pubmed-meshheading:16007523-Retrospective Studies,
pubmed-meshheading:16007523-Risk Factors,
pubmed-meshheading:16007523-Survival Rate
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study.
|
|
pubmed:affiliation |
Research Center of Infection and Immunology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
|
|
pubmed:publicationType |
Journal Article
|
