Source:http://linkedlifedata.com/resource/pubmed/id/16007103
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-9-1
|
| pubmed:abstractText |
In immune-competent individuals, human cytomegalovirus (HCMV) infection is associated with impairment of T-cell function. Our goal was to evaluate prospectively whether clinically asymptomatic HCMV infection in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients, treated pre emptively with ganciclovir, influences T-cell function as well. Mitogen-stimulated T-cell proliferative activity, together with cell surface markers, was tested in 49 patients on days + 30, + 45, + 60, and + 90 after alloHSCT and, additionally, in cases of positive HCMV pp65-antigenemia. HCMV infection was diagnosed in 19 patients. None of them developed HCMV disease. T-cell proliferative activity was significantly decreased on days when HCMV antigenemia was positive as compared to days without antigenemia. The number of pp65-positive cells negatively correlated with proliferative response. Comparison of patients who did experience HCMV infection with those who did not reveals significant decrease of T-cell proliferative activity observed on days + 30 and + 45, a time period when antigenemia was most frequently found to be positive, whereas no difference was detected on days + 60 and + 90. We conclude that, even clinically asymptomatic, HCMV infection has negative impact on T-cell proliferation capacity in alloHSCT recipients. However, pre emptive therapy with ganciclovir makes this immunosuppressive effect transient and restricted to the time of infection duration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0268-3369
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| pubmed:author |
pubmed-author:AvanziniM AMA,
pubmed-author:CampaniniGG,
pubmed-author:Di Cesare MerloneAA,
pubmed-author:GentileRR,
pubmed-author:GiebelSS,
pubmed-author:HolowieckiJJ,
pubmed-author:LilleriDD,
pubmed-author:LocatelliFF,
pubmed-author:MaccarioRR,
pubmed-author:MarconiMM,
pubmed-author:MontagnaDD,
pubmed-author:PagliaraDD,
pubmed-author:TelliSS,
pubmed-author:TravaglinoPP,
pubmed-author:ZeccaMM
|
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
503-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16007103-Adolescent,
pubmed-meshheading:16007103-Adult,
pubmed-meshheading:16007103-Cell Proliferation,
pubmed-meshheading:16007103-Child,
pubmed-meshheading:16007103-Child, Preschool,
pubmed-meshheading:16007103-Cytomegalovirus Infections,
pubmed-meshheading:16007103-Female,
pubmed-meshheading:16007103-Ganciclovir,
pubmed-meshheading:16007103-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16007103-Humans,
pubmed-meshheading:16007103-Immune Tolerance,
pubmed-meshheading:16007103-Infant,
pubmed-meshheading:16007103-Lymphocyte Activation,
pubmed-meshheading:16007103-Male,
pubmed-meshheading:16007103-Mitogens,
pubmed-meshheading:16007103-Premedication,
pubmed-meshheading:16007103-T-Lymphocytes,
pubmed-meshheading:16007103-Time Factors,
pubmed-meshheading:16007103-Transplantation, Homologous
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
The immunosuppressive effect of human cytomegalovirus infection in recipients of allogeneic hematopoietic stem cell transplantation.
|
| pubmed:affiliation |
Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy. sgiebel@poczta.onet.pl
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|