Linked Life Data

16005880

Source:http://linkedlifedata.com/resource/pubmed/id/16005880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-25
pubmed:abstractText
A potential role for the platelet Fc gammaRIIA immunoreceptor (FcR) in collagen-mediated platelet activation associated with diabetes has recently been described. This study was undertaken to prospectively determine which diabetes patient population (type 1, type 2, or both) was more likely to over express platelet FcR and to determine what clinical or laboratory features characterized this population. One hundred and twenty type 2 diabetes, 135 type 1 diabetes, and 275 control patients participated in this cross-sectional study. Relative FcR expression was assessed by flow cytometry of antibody-labeled platelets. FcR expression was higher in type 2 diabetes than in type 1 diabetes or control subjects [mean+/-S.D.=15.17+/-4.66 versus 10.28+/-3.11 (p<0.05) and versus 10.33+/-2.59 (p<0.05), respectively]. This relationship was independent of sex, BMI, HDL cholesterol, triglycerides, blood pressure, glucose control, fibrinogen, and smoking. An inverse association between platelet FcR expression and plasma LDL cholesterol levels was also observed along with a modest correlation with age. Among type 2 patients there was inverse and no correlation between FcR expression and LDL levels and age respectively. Increased platelet FcR expression in type 2 diabetes may play a role in arterial vasoocclusive complications associated with this population. It is hypothesized decreased FcR expression could potentially represent a form of compensatory biological response to an adverse lipid profile in which sensitivity of platelets to collagen may be relatively down regulated in type 2 diabetes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Increased platelet Fc receptor expression in diabetes is limited to those with type 2 disease and low LDL cholesterol levels.
pubmed:affiliation
Department of Medicine, University of Colorado, UCHSC Box B171, 4200 East 9th Avenue, Denver, CO 80262, USA. david.calverley@uchsc.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't