Source:http://linkedlifedata.com/resource/pubmed/id/16005683
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
2005-8-8
|
pubmed:abstractText |
Folding in the endoplasmic reticulum (ER) must couple protein-synthesis pathways operating outside of the compartment with ER-assisted folding (ERAF) pathways in the lumen. Chaperone-mediated folding imbalances that are associated with numerous misfolding diseases, including diabetes, trigger the unfolded-protein response (UPR), using both transcriptional and translational pathways to correct the problem. Recent work suggests that small-molecule inhibitors could be useful to help rebalance protein synthesis with ERAF pathways through the ribosomal initiating factor eIF2alpha. Reprogramming stress pathways with drugs provides a potential new approach for balancing ER-protein load with cellular-folding capacity, thus correcting disease.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates,
http://linkedlifedata.com/resource/pubmed/chemical/ELF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thiourea,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/salubrinal
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1471-4914
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
11
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
347-50
|
pubmed:meshHeading |
pubmed-meshheading:16005683-Animals,
pubmed-meshheading:16005683-Cinnamates,
pubmed-meshheading:16005683-Endoplasmic Reticulum,
pubmed-meshheading:16005683-Humans,
pubmed-meshheading:16005683-Phosphorylation,
pubmed-meshheading:16005683-Protein Biosynthesis,
pubmed-meshheading:16005683-Protein Folding,
pubmed-meshheading:16005683-Thiourea,
pubmed-meshheading:16005683-Transcription Factors
|
pubmed:year |
2005
|
pubmed:articleTitle |
A new pharmacology--drugging stressed folding pathways.
|
pubmed:affiliation |
Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, MB-6, La Jolla, CA 92037, USA.
|
pubmed:publicationType |
Journal Article,
Review
|