Source:http://linkedlifedata.com/resource/pubmed/id/16005623
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2006-2-15
|
| pubmed:abstractText |
Adjustable maintenance dosing with either budesonide/formoterol or budesonide was compared in asthma patients. This double-blind trial randomized 133 patients (mean forced expiratory volume in 1s 66% predicted) to receive 2 inhalations twice daily of budesonide/formoterol 160/4.5 microg (640/18 microg/day) or budesonide 320 microg (1280 microg/day) for 4 weeks. The study drug was adjusted in both groups according to symptoms to 2-4 inhalations daily during Weeks 5-8 and 1-4 inhalations daily during Weeks 9-20. Asthma was well controlled in both groups, with minimal levels of treatment failure (5 budesonide/formoterol vs. 2 budesonide patients; P=NS) and minimal use of reliever therapy. Clinically important improvements in health-related quality of life (HRQL) occurred in the physical functioning and emotional role functioning domains (both P<0.05) for the budesonide/formoterol group compared with budesonide. Physician and patient treatment satisfaction favored budesonide/formoterol (both P<0.05). Budesonide/formoterol patients used fewer daily inhalations of study drug (P=0.024). The median average daily inhaled corticosteroid dose during the study was 448 microg with budesonide/formoterol and 1152 microg with budesonide. Adjustable maintenance dosing with budesonide/formoterol and budesonide resulted in high levels of asthma control. Adjustable budesonide/formoterol treatment achieved greater HRQL benefits and patient satisfaction, with lower overall drug use.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Budesonide,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/formoterol
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0954-6111
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
551-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16005623-Administration, Inhalation,
pubmed-meshheading:16005623-Adult,
pubmed-meshheading:16005623-Aged,
pubmed-meshheading:16005623-Aged, 80 and over,
pubmed-meshheading:16005623-Asthma,
pubmed-meshheading:16005623-Bronchodilator Agents,
pubmed-meshheading:16005623-Budesonide,
pubmed-meshheading:16005623-Double-Blind Method,
pubmed-meshheading:16005623-Drug Administration Schedule,
pubmed-meshheading:16005623-Drug Combinations,
pubmed-meshheading:16005623-Ethanolamines,
pubmed-meshheading:16005623-Female,
pubmed-meshheading:16005623-Forced Expiratory Volume,
pubmed-meshheading:16005623-Humans,
pubmed-meshheading:16005623-Male,
pubmed-meshheading:16005623-Middle Aged,
pubmed-meshheading:16005623-Patient Satisfaction,
pubmed-meshheading:16005623-Quality of Life
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Adjustable maintenance dosing with budesonide/formoterol or budesonide: double-blind study.
|
| pubmed:affiliation |
Grimmenstein Hospital, Landesklinik Hochegg, Hocheggerstrasse 88, A-2840 Grimmenstein, Austria. w.pohl@landesklinik-hochegg.at
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|