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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
Metabotropic glutamate receptor 2 (mGluR2) has been implicated in a variety of CNS disorders, including schizophrenia. Disclosed herein is the development of a new series of allosteric potentiators of mGluR2. Structure-activity relationship studies in conjunction with pharmacokinetic data led to the discovery of indole 5, which is active in an animal model for schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BonnefousCelineC,
pubmed-author:BristowLinda JLJ,
pubmed-author:CampbellUna CUC,
pubmed-author:DaggettLorrie PLP,
pubmed-author:GardnerMichael FMF,
pubmed-author:GovekSteven PSP,
pubmed-author:HutchinsonJohn HJH,
pubmed-author:JamesJoyce KJK,
pubmed-author:KameneckaTheodoreT,
pubmed-author:McQuistonJeffreyJ,
pubmed-author:PracittoRichardR,
pubmed-author:RodriguezDana EDE,
pubmed-author:RoweBlake ABA,
pubmed-author:SchaffhauserHervéH,
pubmed-author:VernierJean-MichelJM,
pubmed-author:ZhaoLucy XLX
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4068-72
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pubmed:meshHeading |
pubmed-meshheading:16005222-Acetophenones,
pubmed-meshheading:16005222-Allosteric Regulation,
pubmed-meshheading:16005222-Animals,
pubmed-meshheading:16005222-Brain,
pubmed-meshheading:16005222-Cross-Linking Reagents,
pubmed-meshheading:16005222-Disease Models, Animal,
pubmed-meshheading:16005222-Humans,
pubmed-meshheading:16005222-Ketamine,
pubmed-meshheading:16005222-Molecular Structure,
pubmed-meshheading:16005222-Rats,
pubmed-meshheading:16005222-Receptors, Metabotropic Glutamate,
pubmed-meshheading:16005222-Schizophrenia,
pubmed-meshheading:16005222-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
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pubmed:affiliation |
Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA. sgovek@san.rr.com
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pubmed:publicationType |
Journal Article
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