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rdf:type |
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lifeskim:mentions |
umls-concept:C0016568,
umls-concept:C0028606,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0243125,
umls-concept:C0376611,
umls-concept:C0449432,
umls-concept:C0699900,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1883254
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-10
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pubmed:abstractText |
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cosmic Dust,
http://linkedlifedata.com/resource/pubmed/chemical/Cytosine,
http://linkedlifedata.com/resource/pubmed/chemical/Formamides,
http://linkedlifedata.com/resource/pubmed/chemical/Iron Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium Silicates,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Silicates,
http://linkedlifedata.com/resource/pubmed/chemical/Uracil,
http://linkedlifedata.com/resource/pubmed/chemical/formamide,
http://linkedlifedata.com/resource/pubmed/chemical/olivine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1439-4227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1368-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16003804-Biogenesis,
pubmed-meshheading:16003804-Catalysis,
pubmed-meshheading:16003804-Cosmic Dust,
pubmed-meshheading:16003804-Cytosine,
pubmed-meshheading:16003804-Formamides,
pubmed-meshheading:16003804-Iron Compounds,
pubmed-meshheading:16003804-Magnesium Compounds,
pubmed-meshheading:16003804-Magnesium Silicates,
pubmed-meshheading:16003804-Mass Spectrometry,
pubmed-meshheading:16003804-Microscopy, Electron, Scanning,
pubmed-meshheading:16003804-Nucleic Acids,
pubmed-meshheading:16003804-Oligonucleotides,
pubmed-meshheading:16003804-Purines,
pubmed-meshheading:16003804-Silicates,
pubmed-meshheading:16003804-Uracil
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and degradation of nucleic Acid components by formamide and cosmic dust analogues.
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pubmed:affiliation |
Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy. saladino@unitus.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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