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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-7-8
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pubmed:abstractText |
Despite prophylactic measures, susceptibility to severe infections in patients who had undergone bone marrow transplantation (BMT) is quite variable. To evaluate the potential role of human leukocyte antigen (HLA)-E polymorphism on the incidence of early infections, we analyzed 77 unrelated-donor (UD) BMT pairs identically matched for classical HLA class I and class II alleles. Multivariate analysis taking into account the patient-, donor- and transplant-related factors showed that bacterial infections and transplant-related mortality (TRM) at day 180 were high when the donor genotype was HLA-E*0101/E*0101 (hazard ratio [HR]=2.20; P=0.03 and HR=2.12, P=0.048, respectively), suggesting that homozygous state for HLA-E*0101 allele is a risk factor for early severe bacterial infections and TRM in UD-BMT.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0041-1337
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pubmed:author |
pubmed-author:BussonMarcM,
pubmed-author:CharronDominiqueD,
pubmed-author:DulphyNicolasN,
pubmed-author:El SherbiniSherif MSM,
pubmed-author:EsperouHélèneH,
pubmed-author:FilionAlainA,
pubmed-author:FortierCatherineC,
pubmed-author:GluckmanElianeE,
pubmed-author:KrishnamoorthyRajagopalR,
pubmed-author:RochaVandersonV,
pubmed-author:SociéGérardG,
pubmed-author:TamouzaRyadR,
pubmed-author:ToubertAntoineA
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-4
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pubmed:dateRevised |
2009-11-30
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pubmed:meshHeading |
pubmed-meshheading:16003246-Adolescent,
pubmed-meshheading:16003246-Adult,
pubmed-meshheading:16003246-Aged,
pubmed-meshheading:16003246-Aged, 80 and over,
pubmed-meshheading:16003246-Bacterial Infections,
pubmed-meshheading:16003246-Bone Marrow Diseases,
pubmed-meshheading:16003246-Bone Marrow Transplantation,
pubmed-meshheading:16003246-Child,
pubmed-meshheading:16003246-Child, Preschool,
pubmed-meshheading:16003246-Cytomegalovirus Infections,
pubmed-meshheading:16003246-Female,
pubmed-meshheading:16003246-HLA Antigens,
pubmed-meshheading:16003246-Histocompatibility Antigens Class I,
pubmed-meshheading:16003246-Humans,
pubmed-meshheading:16003246-Male,
pubmed-meshheading:16003246-Middle Aged,
pubmed-meshheading:16003246-Neoplasms,
pubmed-meshheading:16003246-Polymorphism, Genetic,
pubmed-meshheading:16003246-Postoperative Complications,
pubmed-meshheading:16003246-Tissue Donors
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pubmed:year |
2005
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pubmed:articleTitle |
Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation.
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pubmed:affiliation |
Laboratoire d'Immunologie et d'Histocompatibilité AP-HP, IUH, and INSERM U662, Hôpital Saint-Louis, Paris, France. tamouza@histo.chu-stlouis.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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