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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-7-8
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pubmed:abstractText |
In normal B cell development, a large percentage of newly formed cells bear receptors with high levels of self-reactivity that must be tolerized before entry into the mature B cell pool. We followed the fate of self-reactive B cells expressing high affinity anti-hen egg lysozyme (HEL) Ag receptors exposed in vivo to membrane HEL in a setting in which the anti-HEL L chain was "knocked-in" at the endogenous L chain locus. These mice demonstrated extensive and efficient L chain receptor editing responses and had B cell numbers comparable to those found in animals lacking membrane Ag. BrdU labeling indicated that the time required for editing in response to membrane HEL was approximately 6 h. In mice transgenic for soluble HEL, anti-HEL B cells capable of editing showed evidence for both editing and anergy. These data identify receptor editing as a major physiologic mechanism by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
909-16
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16002689-Animals,
pubmed-meshheading:16002689-Antibody Formation,
pubmed-meshheading:16002689-Antigens, Surface,
pubmed-meshheading:16002689-Autoantigens,
pubmed-meshheading:16002689-B-Lymphocytes,
pubmed-meshheading:16002689-Bone Marrow Cells,
pubmed-meshheading:16002689-Cell Differentiation,
pubmed-meshheading:16002689-Clonal Anergy,
pubmed-meshheading:16002689-Clonal Deletion,
pubmed-meshheading:16002689-Humans,
pubmed-meshheading:16002689-Kinetics,
pubmed-meshheading:16002689-Lymphocyte Activation,
pubmed-meshheading:16002689-Mice,
pubmed-meshheading:16002689-Mice, Inbred C57BL,
pubmed-meshheading:16002689-Mice, Transgenic,
pubmed-meshheading:16002689-Models, Immunological,
pubmed-meshheading:16002689-Muramidase,
pubmed-meshheading:16002689-RNA Editing,
pubmed-meshheading:16002689-Radiation Chimera,
pubmed-meshheading:16002689-Receptors, Antigen, B-Cell,
pubmed-meshheading:16002689-Self Tolerance,
pubmed-meshheading:16002689-Solubility,
pubmed-meshheading:16002689-Spleen
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pubmed:year |
2005
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pubmed:articleTitle |
In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance.
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pubmed:affiliation |
Departments of Medicine and Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Keli.L.Hippen@tc.umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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