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rdf:type |
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lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205373,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1425775,
umls-concept:C1515655,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2005-7-8
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pubmed:abstractText |
The immunoreceptor NKG2D stimulates activation of cytotoxic lymphocytes upon engagement with MHC class I-related NKG2D ligands of which at least some are expressed inducibly upon exposure to carcinogens, cell stress, or viruses. In this study, we investigated consequences of a persistent NKG2D ligand expression in vivo by using transgenic mice expressing MHC class I chain-related protein A (MICA) under control of the H2-K(b) promoter. Although MICA functions as a potent activating ligand of mouse NKG2D, H2-K(b)-MICA mice appear healthy without aberrations in lymphocyte subsets. However, NKG2D-mediated cytotoxicity of H2-K(b)-MICA NK cells is severely impaired in vitro and in vivo. This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequence, H2-K(b)-MICA mice fail to reject MICA-expressing tumors and to mount normal CD8 T cell responses upon Listeria infection emphasizing the importance of NKG2D in immunity against tumors and intracellular infectious agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-2Kb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/MHC class I-related chain A,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
720-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16002667-Animals,
pubmed-meshheading:16002667-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16002667-CHO Cells,
pubmed-meshheading:16002667-Cell Line, Tumor,
pubmed-meshheading:16002667-Coculture Techniques,
pubmed-meshheading:16002667-Cricetinae,
pubmed-meshheading:16002667-Cytotoxicity, Immunologic,
pubmed-meshheading:16002667-Down-Regulation,
pubmed-meshheading:16002667-Graft Rejection,
pubmed-meshheading:16002667-H-2 Antigens,
pubmed-meshheading:16002667-Histocompatibility Antigens Class I,
pubmed-meshheading:16002667-Immunity, Innate,
pubmed-meshheading:16002667-Killer Cells, Natural,
pubmed-meshheading:16002667-Listeriosis,
pubmed-meshheading:16002667-Lymphocyte Activation,
pubmed-meshheading:16002667-Lymphoma, T-Cell,
pubmed-meshheading:16002667-Mice,
pubmed-meshheading:16002667-Mice, Inbred C57BL,
pubmed-meshheading:16002667-Mice, Inbred CBA,
pubmed-meshheading:16002667-Mice, Knockout,
pubmed-meshheading:16002667-Mice, Transgenic,
pubmed-meshheading:16002667-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:16002667-Receptors, Immunologic,
pubmed-meshheading:16002667-Receptors, Natural Killer Cell
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pubmed:year |
2005
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pubmed:articleTitle |
Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.
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pubmed:affiliation |
Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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