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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-11-25
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pubmed:abstractText |
Naturally occurring flavonoids such as quercetin and genistein possess cancer chemopreventive properties in experimental models. However, adverse effects such as their mutagenicity confound their potential clinical usefulness. Furthermore in leukaemia cells some flavonoids cleave the breakpoint cluster region of the mixed lineage leukaemia (MLL) gene as a consequence of inhibition of topoisomerase II. The choice of flavonoids to be developed as cancer chemopreventive agents depends crucially on their safety. Here, we explored safety aspects of the novel flavone tricin, a constituent of rice bran and other grass species, which has recently been found to interfere with murine gastrointestinal carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0344-5704
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pubmed:author |
pubmed-author:BorkhardtArndtA,
pubmed-author:BrogginiMassimoM,
pubmed-author:D'IncalciMaurizioM,
pubmed-author:GescherAndreas JAJ,
pubmed-author:GreavesPeterP,
pubmed-author:HornE CEC,
pubmed-author:KapetanovicIzet MIM,
pubmed-author:RiccioEdE,
pubmed-author:RupaDoppalapudiD,
pubmed-author:StewardWilliam PWP,
pubmed-author:VerschoyleRichard DRD
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16001171-Animals,
pubmed-meshheading:16001171-Anticarcinogenic Agents,
pubmed-meshheading:16001171-Body Weight,
pubmed-meshheading:16001171-Cell Line, Tumor,
pubmed-meshheading:16001171-Chromosome Aberrations,
pubmed-meshheading:16001171-Cricetinae,
pubmed-meshheading:16001171-Cricetulus,
pubmed-meshheading:16001171-DNA Topoisomerases, Type II,
pubmed-meshheading:16001171-Erythrocytes,
pubmed-meshheading:16001171-Escherichia coli,
pubmed-meshheading:16001171-Female,
pubmed-meshheading:16001171-Flavonoids,
pubmed-meshheading:16001171-Gene Rearrangement,
pubmed-meshheading:16001171-Humans,
pubmed-meshheading:16001171-Mice,
pubmed-meshheading:16001171-Mice, Inbred Strains,
pubmed-meshheading:16001171-Micronuclei, Chromosome-Defective,
pubmed-meshheading:16001171-Micronucleus Tests,
pubmed-meshheading:16001171-Mutagenicity Tests,
pubmed-meshheading:16001171-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:16001171-Organ Specificity,
pubmed-meshheading:16001171-Rats,
pubmed-meshheading:16001171-Salmonella typhimurium,
pubmed-meshheading:16001171-Tissue Distribution
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pubmed:year |
2006
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pubmed:articleTitle |
Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.
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pubmed:affiliation |
Department of Cancer Studies, LRI, RKCSB, University of Leicester, Leicester, LE2 7LX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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