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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
Loss of chromosome 11q defines a subset of high-stage aggressive neuroblastomas. Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional candidate tumour suppressor genes. In a previous study, functional evidence for a neuroblastoma suppressor gene on chromosome 11 was obtained through microcell mediated chromosome transfer, indicated by differentiation of neuroblastoma cells with loss of distal 11q upon introduction of chromosome 11. Interestingly, some of these microcell hybrid clones were shown to harbour deletions in the transferred chromosome 11. We decided to further exploit this model system as a means to identify candidate tumour suppressor or differentiation genes located on chromosome 11.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-10490829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-10783264,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-12581896,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-14662434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-14720513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-15331017,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-1679663,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-7040765,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16000168-9801370
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
pubmed-author:BaderScottS,
pubmed-author:CarrPhilippaP,
pubmed-author:CarterNigel PNP,
pubmed-author:De PreterKatleenK,
pubmed-author:EdsjöAndersA,
pubmed-author:FieglerHeikeH,
pubmed-author:MentenBjörnB,
pubmed-author:PåhlmanSvenS,
pubmed-author:SpelemanFrankF,
pubmed-author:Van RoyNadineN,
pubmed-author:VandesompeleJoJ,
pubmed-author:WaelputWimW,
pubmed-author:YigitNurtenN
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16000168-Alleles,
pubmed-meshheading:16000168-Cell Differentiation,
pubmed-meshheading:16000168-Cell Line,
pubmed-meshheading:16000168-Chromosome Deletion,
pubmed-meshheading:16000168-Chromosome Mapping,
pubmed-meshheading:16000168-Chromosomes, Artificial, Bacterial,
pubmed-meshheading:16000168-Chromosomes, Human, Pair 11,
pubmed-meshheading:16000168-Gene Deletion,
pubmed-meshheading:16000168-Genes, Tumor Suppressor,
pubmed-meshheading:16000168-Heterozygote,
pubmed-meshheading:16000168-Humans,
pubmed-meshheading:16000168-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16000168-Microsatellite Repeats,
pubmed-meshheading:16000168-Neuroblastoma,
pubmed-meshheading:16000168-Nucleic Acid Hybridization,
pubmed-meshheading:16000168-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16000168-Phalloidine,
pubmed-meshheading:16000168-Phenotype,
pubmed-meshheading:16000168-RNA, Messenger,
pubmed-meshheading:16000168-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2005
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pubmed:articleTitle |
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11.
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pubmed:affiliation |
Center for Medical Genetics, Ghent University Hospital, MRB 2nd floor, De Pintelaan 185, B-9000 Ghent, Belgium. katleen.depreter@ugent.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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