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pubmed-article:15999805pubmed:abstractTextIn order to better understand the genetic factors that initiate systemic lupus erythematosus (SLE), we are using both linkage and association approaches to identify susceptibility genes for the disease. Association studies have recently identified three HLA Class II haplotypes as well as a functional missense polymorphism in protein tyrosine phosphatase (PTP) PTPN22 as important risk alleles for SLE. Here, we will review these data, and explain how these findings contribute to an understanding of the genetic architecture of human SLE.lld:pubmed
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pubmed-article:15999805pubmed:pagination145-60; discussion 160-4lld:pubmed
pubmed-article:15999805pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15999805pubmed:articleTitleProgress towards understanding the genetic pathogenesis of systemic lupus erythematosus.lld:pubmed
pubmed-article:15999805pubmed:affiliationDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, 55455, USA.lld:pubmed
pubmed-article:15999805pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15999805pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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