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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-7-7
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pubmed:abstractText |
In order to better understand the genetic factors that initiate systemic lupus erythematosus (SLE), we are using both linkage and association approaches to identify susceptibility genes for the disease. Association studies have recently identified three HLA Class II haplotypes as well as a functional missense polymorphism in protein tyrosine phosphatase (PTP) PTPN22 as important risk alleles for SLE. Here, we will review these data, and explain how these findings contribute to an understanding of the genetic architecture of human SLE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1528-2511
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pubmed:author |
pubmed-author:BaechlerEmily CEC,
pubmed-author:BauerJasonJ,
pubmed-author:BehrensTimothy WTW,
pubmed-author:GaffneyPatrick MPM,
pubmed-author:GillettClarenceC,
pubmed-author:GrahamRobert RRR,
pubmed-author:GregersenPeter KPK,
pubmed-author:HippenKeli LKL,
pubmed-author:KyogokuChiekoC,
pubmed-author:LangefeldCarl DCD,
pubmed-author:MoserKathy LKL,
pubmed-author:OrtmannWard AWA,
pubmed-author:PetersonErikE,
pubmed-author:RamosPaula SPS
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pubmed:issnType |
Print
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pubmed:volume |
267
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-60; discussion 160-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15999805-Alleles,
pubmed-meshheading:15999805-HLA Antigens,
pubmed-meshheading:15999805-Haplotypes,
pubmed-meshheading:15999805-Humans,
pubmed-meshheading:15999805-Lupus Erythematosus, Systemic,
pubmed-meshheading:15999805-Mutation, Missense,
pubmed-meshheading:15999805-Polymorphism, Genetic,
pubmed-meshheading:15999805-Protein Tyrosine Phosphatases
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pubmed:year |
2005
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pubmed:articleTitle |
Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus.
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pubmed:affiliation |
Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, 55455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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