15998902

Source:http://linkedlifedata.com/resource/pubmed/id/15998902

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0034897, umls-concept:C0282460, umls-concept:C0796512, umls-concept:C1518419, umls-concept:C1621958, umls-concept:C1707080, umls-concept:C2603343
pubmed:issue	23
pubmed:dateCreated	2005-8-10
pubmed:abstractText	Temsirolimus (CCI-779) is a small-molecule inhibitor of the mammalian target of rapamycin (mTOR) and represents a rational therapeutic target against glioblastoma multiforme (GBM).
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA25224, http://linkedlifedata.com/resource/pubmed/grant/M01 RR00585-34, http://linkedlifedata.com/resource/pubmed/grant/R21 CA99209
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309333
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating, http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase, http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus, http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/temsirolimus
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0732-183X
pubmed:author	pubmed-author:BallmanKarlaK, pubmed-author:BonoLL, pubmed-author:BucknerJan CJC, pubmed-author:DakhilShaker RSR, pubmed-author:DanceyJanetJ, pubmed-author:GalanisEvanthiaE, pubmed-author:HidalgoManuelM, pubmed-author:JaeckleKurt AKA, pubmed-author:JenkinsRobert BRB, pubmed-author:KreisbergJeffrey IJI, pubmed-author:MaurerMatthew JMJ, pubmed-author:MortonRoscoe FRF, pubmed-author:North Central Cancer Treatment Group, pubmed-author:PeralbaJosep MJM, pubmed-author:ScheithauerBernd WBW, pubmed-author:WalshDaniel JDJ
pubmed:issnType	Print
pubmed:day	10
pubmed:volume	23
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5294-304
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:15998902-Adult, pubmed-meshheading:15998902-Aged, pubmed-meshheading:15998902-Antineoplastic Agents, Alkylating, pubmed-meshheading:15998902-Brain Neoplasms, pubmed-meshheading:15998902-Disease-Free Survival, pubmed-meshheading:15998902-Female, pubmed-meshheading:15998902-Genes, erbB-1, pubmed-meshheading:15998902-Glioblastoma, pubmed-meshheading:15998902-Humans, pubmed-meshheading:15998902-Male, pubmed-meshheading:15998902-Middle Aged, pubmed-meshheading:15998902-Neoplasm Recurrence, Local, pubmed-meshheading:15998902-PTEN Phosphohydrolase, pubmed-meshheading:15998902-Phosphoric Monoester Hydrolases, pubmed-meshheading:15998902-Prognosis, pubmed-meshheading:15998902-Protein Kinase Inhibitors, pubmed-meshheading:15998902-Protein Kinases, pubmed-meshheading:15998902-Salvage Therapy, pubmed-meshheading:15998902-Sirolimus, pubmed-meshheading:15998902-TOR Serine-Threonine Kinases, pubmed-meshheading:15998902-Treatment Outcome, pubmed-meshheading:15998902-Tumor Suppressor Proteins
pubmed:year	2005
pubmed:articleTitle	Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study.
pubmed:affiliation	Mayo Clinic and Mayo Foundation, 200 First St SW, Rochester, MN 55905, USA. galanis.evanthia@mayo.edu
pubmed:publicationType	Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Clinical Trial, Phase II, Research Support, N.I.H., Extramural