|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2005-7-4
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|
pubmed:abstractText |
Interleukin 1 (IL-1) plays a pivotal role in the pathogenesis of osteoarthritis (OA). In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease. We examined the safety of intraarticular (IA) injections of recombinant human IL-1Ra in patients with knee OA.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0315-162X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
32
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1317-23
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:15996071-Aged,
pubmed-meshheading:15996071-Analgesics,
pubmed-meshheading:15996071-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15996071-Antirheumatic Agents,
pubmed-meshheading:15996071-Female,
pubmed-meshheading:15996071-Humans,
pubmed-meshheading:15996071-Injections, Intra-Articular,
pubmed-meshheading:15996071-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:15996071-Interleukin-1,
pubmed-meshheading:15996071-Male,
pubmed-meshheading:15996071-Middle Aged,
pubmed-meshheading:15996071-Osteoarthritis, Knee,
pubmed-meshheading:15996071-Pain,
pubmed-meshheading:15996071-Patient Satisfaction,
pubmed-meshheading:15996071-Prospective Studies,
pubmed-meshheading:15996071-Severity of Illness Index,
pubmed-meshheading:15996071-Sialoglycoproteins
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study.
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|
pubmed:affiliation |
Department of Rheumatology, Hospital Henri Mondor, University Paris XII, Paris, France. xavier.chevalier@hmn.ap-hop-paris.fr
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
