|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2005-7-4
|
|
pubmed:abstractText |
We investigated the mechanism of resistance to genital herpes simplex virus type 2 (HSV-2) infection in mice transfected with the murine alpha-1 interferon (IFN-alpha1) transgene. In situ transfection of mice with the IFN-alpha1 transgene resulted in an elevation in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissue. Coupled with the finding that mice lacking a functional PKR pathway were no longer resistant to genital HSV-2 infection following transfection with the IFN-alpha1 transgene in comparison to wild-type mice or mice lacking a functional OAS pathway, these results suggest that PKR is the dominant antiviral pathway activated by the IFN-alpha1 transgene.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10201945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10366565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10366581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10400730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10792501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-10793004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11120814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11160227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11207303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11404376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11413339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11801642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-11836383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12050378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12162875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12388699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12502811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12663762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12915549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12941930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-12951027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-209470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-2783720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-7571418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-8145530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-8557029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-9123869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-9335431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-9525585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-9759489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994831-9794439
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
79
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
9341-5
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:15994831-Animals,
pubmed-meshheading:15994831-Herpes Genitalis,
pubmed-meshheading:15994831-Interferon-alpha,
pubmed-meshheading:15994831-Mice,
pubmed-meshheading:15994831-Mice, Inbred C57BL,
pubmed-meshheading:15994831-Mice, Inbred ICR,
pubmed-meshheading:15994831-Transfection,
pubmed-meshheading:15994831-Transgenes,
pubmed-meshheading:15994831-eIF-2 Kinase
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2.
|
|
pubmed:affiliation |
Department of Ophthalmology, DMEI #415, The University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA. dan-carr@ouhsc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|
