| pubmed-article:15994824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C0376526 | lld:lifeskim |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:15994824 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:15994824 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15994824 | pubmed:dateCreated | 2005-7-4 | lld:pubmed |
| pubmed-article:15994824 | pubmed:abstractText | MicroRNAs (miRNAs) are small, noncoding regulatory RNA molecules that bind to 3' untranslated regions (UTRs) of mRNAs to either prevent their translation or induce their degradation. Previously identified in a variety of organisms ranging from plants to mammals, miRNAs are also now known to be produced by viruses. The human gammaherpesvirus Epstein-Barr virus has been shown to encode miRNAs, which potentially regulate both viral and cellular genes. To determine whether Kaposi's sarcoma-associated herpesvirus (KSHV) encodes miRNAs, we cloned small RNAs from KSHV-positive primary effusion lymphoma-derived cells and endothelial cells. Sequence analysis revealed 11 isolated RNAs of 19 to 23 bases in length that perfectly align with KSHV. Surprisingly, all candidate miRNAs mapped to a single genomic locale within the latency-associated region of KSHV. These data suggest that viral and host cellular gene expression may be regulated by miRNAs during both latent and lytic KSHV replication. | lld:pubmed |
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| pubmed-article:15994824 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15994824 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15994824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15994824 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15994824 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15994824 | pubmed:author | pubmed-author:RenneRolfR | lld:pubmed |
| pubmed-article:15994824 | pubmed:author | pubmed-author:HuJianhongJ | lld:pubmed |
| pubmed-article:15994824 | pubmed:author | pubmed-author:SamolsMark... | lld:pubmed |
| pubmed-article:15994824 | pubmed:author | pubmed-author:SkalskyRebecc... | lld:pubmed |
| pubmed-article:15994824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15994824 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:15994824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15994824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15994824 | pubmed:pagination | 9301-5 | lld:pubmed |
| pubmed-article:15994824 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15994824 | pubmed:meshHeading | pubmed-meshheading:15994824... | lld:pubmed |
| pubmed-article:15994824 | pubmed:meshHeading | pubmed-meshheading:15994824... | lld:pubmed |
| pubmed-article:15994824 | pubmed:meshHeading | pubmed-meshheading:15994824... | lld:pubmed |
| pubmed-article:15994824 | pubmed:meshHeading | pubmed-meshheading:15994824... | lld:pubmed |
| pubmed-article:15994824 | pubmed:meshHeading | pubmed-meshheading:15994824... | lld:pubmed |
| pubmed-article:15994824 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15994824 | pubmed:articleTitle | Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. | lld:pubmed |
| pubmed-article:15994824 | pubmed:affiliation | Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA. | lld:pubmed |
| pubmed-article:15994824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15994824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15994824 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15994824 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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