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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
MicroRNAs (miRNAs) are small, noncoding regulatory RNA molecules that bind to 3' untranslated regions (UTRs) of mRNAs to either prevent their translation or induce their degradation. Previously identified in a variety of organisms ranging from plants to mammals, miRNAs are also now known to be produced by viruses. The human gammaherpesvirus Epstein-Barr virus has been shown to encode miRNAs, which potentially regulate both viral and cellular genes. To determine whether Kaposi's sarcoma-associated herpesvirus (KSHV) encodes miRNAs, we cloned small RNAs from KSHV-positive primary effusion lymphoma-derived cells and endothelial cells. Sequence analysis revealed 11 isolated RNAs of 19 to 23 bases in length that perfectly align with KSHV. Surprisingly, all candidate miRNAs mapped to a single genomic locale within the latency-associated region of KSHV. These data suggest that viral and host cellular gene expression may be regulated by miRNAs during both latent and lytic KSHV replication.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-10208923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-10364323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-10622254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-11017143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-12414930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-12592000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-12679032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-12829841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-14657504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-14681370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-14709173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-14744438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15118162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15372042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15525642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15601472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15610730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-15692053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-7632932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-7700311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-7997879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-8612236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-8939871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-8962146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-9151804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994824-9733875
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9301-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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