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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0079419,
umls-concept:C0086418,
umls-concept:C0151686,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0334227,
umls-concept:C1421293,
umls-concept:C2700100,
umls-concept:C2911684
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pubmed:issue |
14
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|
pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation. Here, we report that downregulation of E6-AP expression by RNA interference results in both the accumulation of p53 and growth suppression of the HPV-positive cervical cancer cell lines HeLa and SiHa. In addition, HeLa cells, in which p53 expression was suppressed by RNA interference, are significantly less sensitive to the downregulation of E6-AP expression with respect to growth suppression than parental HeLa cells. These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-10757806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-10829072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-10864652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11027293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11158620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11373684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11395416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11747320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11753670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11910072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-11917093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12036950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12044010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12507556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12507557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12932734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12944990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-12955072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-14507994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-14707283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-15731267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-7657167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-8221889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-8380895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-9053858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-9143503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-9497376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994823-9879999
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9296-300
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15994823-Down-Regulation,
pubmed-meshheading:15994823-Female,
pubmed-meshheading:15994823-HeLa Cells,
pubmed-meshheading:15994823-Humans,
pubmed-meshheading:15994823-Papillomaviridae,
pubmed-meshheading:15994823-RNA, Small Interfering,
pubmed-meshheading:15994823-RNA Interference,
pubmed-meshheading:15994823-Tumor Suppressor Protein p53,
pubmed-meshheading:15994823-Ubiquitin-Protein Ligases,
pubmed-meshheading:15994823-Uterine Cervical Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
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pubmed:affiliation |
Center for Biochemistry, Faculty of Medicine, University of Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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