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rdf:type |
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lifeskim:mentions |
umls-concept:C0005955,
umls-concept:C0006556,
umls-concept:C0008051,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0204727,
umls-concept:C0205250,
umls-concept:C0205409,
umls-concept:C0679058,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1522642,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
1992-7-9
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10713,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10714,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10715,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10915,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10916,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10917,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10918,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10919,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10920,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X64743,
http://linkedlifedata.com/resource/pubmed/xref/PIR/A27121,
http://linkedlifedata.com/resource/pubmed/xref/PIR/A32471,
http://linkedlifedata.com/resource/pubmed/xref/PIR/A35328,
http://linkedlifedata.com/resource/pubmed/xref/PIR/A39035,
http://linkedlifedata.com/resource/pubmed/xref/PIR/B35328
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pubmed:abstractText |
The RNase gene superfamily combines functionally divergent proteins which share statistically significant sequence similarity. Known members assigned to this family include secretory and nonsecretory RNases; angiogenin; eosinophil cationic protein; eosinophil-derived neurotoxin; sialic-acid binding lectin and anti-tumor protein P-30. We report the cDNA cloning of the chicken RNase Super Family Related (RSFR) gene that is specifically overexpressed in normal bone marrow cells and bone marrow-derived AMV transformed monoblasts. It codes for a 139 amino acid protein with a putative signal peptide and remarkable conservation of active-site residues, other residues known to be important for substrate binding and catalytic activity and half-cystine residues common for all RNase family members. Phylogenetic tree analysis shows that RSFR defines a new group of genes within the family. We also conclude that an amino acid sequence block CKXXNTF(X) 11C is a "shortest RNase superfamily signature" which is both necessary and sufficient to identify all previously recognized family members as well as chicken RSFR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1599460-Amino Acid Sequence,
pubmed-meshheading:1599460-Animals,
pubmed-meshheading:1599460-Base Sequence,
pubmed-meshheading:1599460-Bone Marrow,
pubmed-meshheading:1599460-Cell Line,
pubmed-meshheading:1599460-Chickens,
pubmed-meshheading:1599460-DNA, Single-Stranded,
pubmed-meshheading:1599460-Molecular Sequence Data,
pubmed-meshheading:1599460-Multigene Family,
pubmed-meshheading:1599460-Phylogeny,
pubmed-meshheading:1599460-Ribonucleases,
pubmed-meshheading:1599460-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1599460-Tissue Distribution
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pubmed:year |
1992
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pubmed:articleTitle |
Isolation of a cDNA clone encoding the RNase-superfamily-related gene highly expressed in chicken bone marrow cells.
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pubmed:affiliation |
Institute of Carcinogenesis: All-Union Cancer Research Center, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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