| pubmed-article:15994334 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C0015350 | lld:lifeskim |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C0030281 | lld:lifeskim |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C1256369 | lld:lifeskim |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C0332261 | lld:lifeskim |
| pubmed-article:15994334 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15994334 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:15994334 | pubmed:dateCreated | 2005-8-22 | lld:pubmed |
| pubmed-article:15994334 | pubmed:abstractText | Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages beta1 integrins to induce spreading, improve glucose-stimulated insulin secretion (GSIS), and increase survival of pancreatic beta cells. The present study examines whether 804G-ECM activates the transcriptional activity of NF-kappaB and the involvement of NF-kappaB in those effects of 804G-ECM on pancreatic beta cells. 804G-ECM induces nuclear translocation and the DNA binding activity of the p65 subunit of NF-kappaB. 804G-ECM-induced nuclear translocation of NF-kappaB was weak as compared with that induced by interleukin-1beta. Transient 804G-ECM-induced DNA binding activity of NF-kappaB (peak at 2 h) and overexpression of NF-kappaB target genes IkappaB alpha and NF-kappaB1(p105) (peak at 4 h) were observed. When NF-kappaB was inhibited by an inhibitor of IkappaB alpha phosphorylation (Bay 11-7082) or by a recombinant adenovirus expressing the nonphosphorylatable form of IkappaB alpha, 804G-ECM-induced cell spreading and actin cytoskeleton organization were reduced. GSIS from cells on 804G-ECM was inhibited 5-fold, whereas cell survival was not affected. In summary, the results indicate that 804G-ECM induces a transient and moderate NF-kappaB activity. This study shows for the first time that ECM-induced NF-kappaB activity is necessary in maintaining GSIS, although it does not affect survival of pancreatic beta cells. The effects of ECM-induced NF-kappaB activity contrast with the deleterious effects of cytokine-induced NF-kappaB activity. It is proposed that transient and moderate NF-kappaB activity is essential for proper function of the pancreatic beta cell. | lld:pubmed |
| pubmed-article:15994334 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15994334 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994334 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15994334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15994334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994334 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15994334 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15994334 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:HalbanPhilipp... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:BoscoDomenico... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:RibauxPascale... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:IrmingerJean-... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:RickenbachKat... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:ParnaudGérald... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:RouillerDomin... | lld:pubmed |
| pubmed-article:15994334 | pubmed:author | pubmed-author:HammarEva BEB | lld:pubmed |
| pubmed-article:15994334 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15994334 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:15994334 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15994334 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15994334 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15994334 | pubmed:pagination | 30630-7 | lld:pubmed |
| pubmed-article:15994334 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15994334 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15994334 | pubmed:articleTitle | Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. | lld:pubmed |
| pubmed-article:15994334 | pubmed:affiliation | Department of Genetic Medicine and Development, University Medical Center, University Hospital, 1211 Geneva 4, Switzerland. eva.hammar@medecine.unige.ch | lld:pubmed |
| pubmed-article:15994334 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15994334 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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