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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-9-1
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pubmed:abstractText |
The pathophysiology of asthma involves the action of inflammatory/allergic lipid mediators formed following membrane phospholipid hydrolysis by phospholipase A(2) (PLA(2)). Cysteinyl leukotrienes are considered potent inducers of bronchoconstriction and airway remodelling. Ovalbumin (OVA) induced bronchoconstriction in rats is associated with increased secretory PLA(2) (sPLA(2)) activation and cysteinyl leukotriene production, together with suppression of cytosolic PLA(2) and prostaglandin E(2). These processes are reversed when the animals are pretreated systemically with an extracellular cell impermeable sPLA(2) inhibitor which also suppresses the early allergic reaction to OVA challenge. In this study we examine the capacity of the sPLA(2) inhibitor to ameliorate inflammatory and allergic manifestations (early and late bronchoconstriction) of OVA induced allergic bronchitis in rats when the inhibitor was administered by inhalation to confine it to the airways.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-10077051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-10331081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-10465666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-10669307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-10671511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11080687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11264706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11275266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11285383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11591736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-11934806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12069834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12100016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12432910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12495641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12532084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12626587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12724134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12750406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12796497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12847398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-12895591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-14603468,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-8612796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-9017783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-9309991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15994250-9558359
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0040-6376
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Treatment of ovalbumin-induced experimental allergic bronchitis in rats by inhaled inhibitor of secretory phospholipase A(2).
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pubmed:affiliation |
Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel 91120.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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