Linked Life Data

15994024

Source:http://linkedlifedata.com/resource/pubmed/id/15994024

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-8-15
pubmed:abstractText
Numerous factors modulate neurogenesis in the adult dentate gyrus and subventricular zone, but it is often not clear if the modulation is mediated by direct effects on the proliferating and differentiating cells or secondary to effects on other cells. Also, while some factors selectively affect neurogenesis in one of the neurogenetic zones, it is not clear how selectivity is achieved. Estrogen is a hormonal modulator of neurogenesis. To address the issues of direct versus indirect control and regional specificity we investigated the colocalization of immunoreactivity for a proliferating cell marker, Ki-67, and a marker for migrating and differentiating cells with a neuronal phenotype, doublecortin, with the expressions of mRNA for estrogen receptors alpha and beta. We found an extensive colocalization of estrogen receptor alpha with both markers in the dentate gyrus and only with Ki-67 in the subventricular zone. An extensive colocalization of estrogen receptor beta with both markers was found in the dentate gyrus, but only a few Ki-67-immunoreactive and no doublecortin-immunoreactive cells of the subventricular zone expressed estrogen receptor beta mRNA. Estrogen receptor alpha and beta mRNAs were not expressed in other telencephalic Ki-67-immunoreactive cells or in constitutively doublecortin-immunoreactive cells of the piriform cortex. The extensive colocalization of immunoreactive markers for cell proliferation and differentiation with mRNAs for estrogen receptor alpha and estrogen receptor beta points to the direct modulation of dentate cell proliferation, differentiation and survival by estrogen, while direct effects of estrogen in the subventricular zone appear restricted to estrogen receptor alpha-mediated effects operating at the time of cell proliferation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
847-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15994024-Animals, pubmed-meshheading:15994024-Cell Count, pubmed-meshheading:15994024-Cell Differentiation, pubmed-meshheading:15994024-Cell Proliferation, pubmed-meshheading:15994024-Cerebral Ventricles, pubmed-meshheading:15994024-Dentate Gyrus, pubmed-meshheading:15994024-Diagnostic Imaging, pubmed-meshheading:15994024-Estrogen Receptor alpha, pubmed-meshheading:15994024-Estrogen Receptor beta, pubmed-meshheading:15994024-Gene Expression Regulation, pubmed-meshheading:15994024-Immunohistochemistry, pubmed-meshheading:15994024-In Situ Hybridization, pubmed-meshheading:15994024-Ki-67 Antigen, pubmed-meshheading:15994024-Male, pubmed-meshheading:15994024-Microtubule-Associated Proteins, pubmed-meshheading:15994024-Neuropeptides, pubmed-meshheading:15994024-RNA, Messenger, pubmed-meshheading:15994024-Rats, pubmed-meshheading:15994024-Rats, Sprague-Dawley
pubmed:year
2005
pubmed:articleTitle
Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone.
pubmed:affiliation
Department of Biomedical Science, Charles E. Schmidt Biomedical Center, Florida Atlantic University, Boca Raton, FL 33431-0991, USA. cisgor@fau.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural