Source:http://linkedlifedata.com/resource/pubmed/id/15993720
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 healthy controls. HLA-DRB1*0803 (27.8% vs. 14.5% in controls, OR = 2.27, corrected p [p(c)] = 0.03) and *1602 (5.1% vs. 0%, OR = 22.34, p(c) = 0.03) alleles and closely linked haplotypes, DRB1*0803-DQB1*0601 and DRB1*1602-DQB1*0502, conferred susceptibility to GD in Koreans. Weak association of DRB1*0301 with GD susceptibility was observed in male patients only (12.5% vs. 3.5%, OR = 3.57, p < 0.05). HLA-DRB1*0101, *0701, *1202, and *1302 alleles were weakly associated with resistance to the disease (OR < 0.5, p < 0.05). Some HLA alleles were weakly associated with clinical characteristics in GD patients. Patients with DRB1*1301-DQB1*0603 developed their diseases in younger ages and were more frequently associated with larger goiter (p < 0.05). Although HLA class II alleles associated with GD in Koreans were different from those in Caucasians, some associations are shared, such as association of DRB1*0301 in male patients and protective effect of DRB1*0701 to GD susceptibility.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0198-8859
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
741-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15993720-Adolescent,
pubmed-meshheading:15993720-Adult,
pubmed-meshheading:15993720-Aged,
pubmed-meshheading:15993720-Alleles,
pubmed-meshheading:15993720-Female,
pubmed-meshheading:15993720-Gene Frequency,
pubmed-meshheading:15993720-Graves Disease,
pubmed-meshheading:15993720-HLA-DQ Antigens,
pubmed-meshheading:15993720-HLA-DR Antigens,
pubmed-meshheading:15993720-Humans,
pubmed-meshheading:15993720-Korea,
pubmed-meshheading:15993720-Male,
pubmed-meshheading:15993720-Middle Aged,
pubmed-meshheading:15993720-Polymorphism, Single-Stranded Conformational
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pubmed:year |
2005
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pubmed:articleTitle |
Association of HLA-DR and -DQ genes with Graves disease in Koreans.
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pubmed:affiliation |
Department of Laboratory Medicine, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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