Linked Life Data

15993717

Source:http://linkedlifedata.com/resource/pubmed/id/15993717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-7-4
pubmed:abstractText
Matrix metalloproteinases (MMPs), such as stromelysin-1 (MMP-3), are a family of enzymes important in resorption and remodeling of the extracellular matrix whose degradation may play a role in the villous atrophy characteristic of celiac disease (CD). We investigated the association between the polymorphism at position -1171 of the MMP-3 gene and susceptibility to CD in 225 Italian patients and 170 controls previously typed for human leukocyte antigen (HLA) class II genes. We also evaluated sex differences in the effect of this polymorphism on disease risk. A male-specific association of the 5A/6A polymorphism with CD was observed. The frequencies of 6A allele and 6A/6A genotype in affected male subjects were significantly above those observed both in male controls (p = 4.1 x 10(-3) and p = 3.4 x 10(-3); odds ratio = 2.4, 95% confidence interval 1.3-4.3) and in female patients (p = 2.7 x 10(-4) and p = 6.2 x 10(-4)). This is the first demonstration of a sex-specific association between the MMP-3 promoter polymorphism and CD. Homozygosity for the 6A allele appears as a risk factor for CD only in men, which is different from the HLA susceptibility alleles that confer a higher risk in women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
716-20
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects.
pubmed:affiliation
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article