Source:http://linkedlifedata.com/resource/pubmed/id/15993715
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0013018,
umls-concept:C0018956,
umls-concept:C0021760,
umls-concept:C0030705,
umls-concept:C0035647,
umls-concept:C0037047,
umls-concept:C0085295,
umls-concept:C0086860,
umls-concept:C0332281,
umls-concept:C0678951,
umls-concept:C0856825,
umls-concept:C1504389,
umls-concept:C1515895,
umls-concept:C1527169
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| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-7-4
|
| pubmed:abstractText |
The present study aimed to determine existing associations between single nucleotide polymorphisms within the promoters of interleukin (IL)-6 (-174 G/C) and IL-10 (-1082 G/A, -819 C/T, -592 C/A) genes and the outcome of allogeneic sibling hematopoietic stem cell transplantation. Ninety-three recipients and 74 donors were typed for IL-6 and IL-10 alleles by polymerase chain reaction-sequence specific primer. Then, IL-6 activity in patient serum and the concentration of C-reactive protein were analyzed at various times after transplantation in relation to transplant complications and IL-6 genotype. IL-6 activity in serum was significantly higher in patients who died as a result of toxic complications and after the 6 weeks after transplantation in patients with severe acute graft-versus-host disease (aGVHD). Recipient IL-6 G genotype was associated with increased IL-6 activity and C-reactive protein production. In univariate analyses, recipient IL-6 G and donor IL-6 GG associated or tended to associate with increased risk for aGVHD. In contrast, recipient IL-10 GCC/GCC and donor IL-10 ACC decreased the risk of aGVHD. IL-6 and IL-10 polymorphic features, together with other factors known to affect the risk of aGVHD, were also subjected to multivariate analyses. These analyses confirmed the independent contribution of recipient IL-10 GCC/GCC (odds ratio = 0.085, p = 0.046) and donor IL-6 GG (odds ratio = 3.934, p = 0.034) genotypes to the risk of aGVHD.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0198-8859
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
700-10
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15993715-Acute Disease,
pubmed-meshheading:15993715-Adolescent,
pubmed-meshheading:15993715-Adult,
pubmed-meshheading:15993715-C-Reactive Protein,
pubmed-meshheading:15993715-Child,
pubmed-meshheading:15993715-Child, Preschool,
pubmed-meshheading:15993715-Female,
pubmed-meshheading:15993715-Genetic Predisposition to Disease,
pubmed-meshheading:15993715-Genotype,
pubmed-meshheading:15993715-Graft vs Host Disease,
pubmed-meshheading:15993715-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15993715-Hematopoietic Stem Cells,
pubmed-meshheading:15993715-Humans,
pubmed-meshheading:15993715-Interleukin-10,
pubmed-meshheading:15993715-Interleukin-6,
pubmed-meshheading:15993715-Male,
pubmed-meshheading:15993715-Middle Aged,
pubmed-meshheading:15993715-Multivariate Analysis,
pubmed-meshheading:15993715-Polymorphism, Genetic,
pubmed-meshheading:15993715-Promoter Regions, Genetic,
pubmed-meshheading:15993715-Risk Factors,
pubmed-meshheading:15993715-Tissue Donors
|
| pubmed:year |
2005
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| pubmed:articleTitle |
IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease.
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| pubmed:affiliation |
Lower Silesian Center for Cellular Transplantation and National Polish Bone Marrow Donor Registry, Wroclaw, Poland. lkarabon@wp.pl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|