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pubmed-article:15993608pubmed:abstractTextThe induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A-D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM).lld:pubmed
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pubmed-article:15993608pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15993608pubmed:articleTitleLibertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition.lld:pubmed
pubmed-article:15993608pubmed:affiliationCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA.lld:pubmed
pubmed-article:15993608pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15993608pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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