Linked Life Data

15993608

Source:http://linkedlifedata.com/resource/pubmed/id/15993608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2005-7-29
pubmed:abstractText
The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A-D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5267-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition.
pubmed:affiliation
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural